Publicaties
Evaluation of response to neoadjuvant chemotherapy in osteosarcoma using dynamic contrast-enhanced MRI : development and external validation of a model Universiteit Gent
ObjectiveTo identify which dynamic contrast-enhanced (DCE-)MRI features best predict histological response to neoadjuvant chemotherapy in patients with an osteosarcoma.MethodsPatients with osteosarcoma who underwent DCE-MRI before and after neoadjuvant chemotherapy prior to resection were retrospectively included at two different centers. Data from the center with the larger cohort (training cohort) was used to identify which method for ...
Diagnosis and monitoring denosumab therapy of giant cell tumors of bone : radiologic-pathologic correlation Universiteit Gent
ObjectiveTo determine the value of CT and dynamic contrast-enhanced (DCE-)MRI for monitoring denosumab therapy of giant cell tumors of bone (GCTB) by correlating it to histopathology.Materials and methodsPatients with GCTB under denosumab treatment and monitored with CT and (DCE-)MRI (2012-2021) were retrospectively included. Imaging and (semi-)quantitative measurements were used to assess response/relapse. Tissue samples were analyzed using ...
Performance of an MRI scoring system for inflammation of joints and entheses in peripheral SpA : post-hoc analysis of the CRESPA trial Universiteit Gent Vlaams Instituut voor Biotechnologie
Objectives: The aim of this study was to investigate the reliability, validity, and sensitivity to change of a novel MRI scoring system in early peripheral SpA (pSpA). Methods: MRI of the pelvis and lower extremities was performed before initiation of the TNF inhibitor golimumab in 56 patients and repeated in 46 patients who achieved sustained clinical remission after 24, 36 or 48 weeks. Three readers applied a semi-quantitative MRI scoring ...
Magnetic resonance imaging of synovial tumor and tumorlike conditions Universiteit Gent
Due to its unparalleled soft tissue resolution and multiplanar imaging capability, MRI is the modality of choice for imaging synovial tumor and tumorlike lesions. The minimal hardware requirements, imaging protocol, and either basic or advanced MR sequences are described. For lesion characterization, four major groups can be distinguished based on the analysis of signal intensities on T1- and T2-weighted images. Furthermore, this chapter gives ...
Clash of the titans : current CT and CT-like imaging modalities in sacroiliitis in spondyloarthritis Universiteit Gent
Internal derangement of the knee : cartilage and osteochondral injuries Universiteit Gent
Osteochondral lesions can be caused by osteochondritis dissecans, insufficiency fractures, and posttraumatic osteochondral fractures. It is sometimes impossible to differentiate among the three entities, as discussed in text. MRI, possibly with intravenous contrast agent administration, can unambiguously differentiate between stable and unstable osteochondritis dissecans based on the presence or absence of a high signal intensity line beneath ...
Plasmacytoma Universiteit Gent
Solitary plasmacytoma of bone is one of many existing types of bone tumors and is part of the plasma cell disorder spectrum. It is a local clonal plasma cell proliferation without evidence of symptomatic multiple myeloma. It occurs slightly more frequently in males with a median age at diagnosis of 55 years. The thoracic vertebrae are most frequently involved. The exact etiology is unknown, although a role for acquired B-cell defects is ...
Machine learning pipeline for predicting bone marrow edema along the sacroiliac joints on magnetic resonance imaging Universiteit Gent Vlaams Instituut voor Biotechnologie
Objective To develop and validate a fully automated machine learning (ML) algorithm that predicts bone marrow oedema (BMO) on a quadrant-level in sacroiliac (SI) joint MRI. Methods A computer vision workflow automatically locates the SI joints, segments regions of interest (ilium and sacrum), performs objective quadrant extraction and predicts presence of BMO, suggestive of inflammatory lesions, on a quadrant-level in semi-coronal slices of ...
Erdheim-Chester disease : diffusion-weighted imaging and dynamic contrast-enhanced MRI provide useful information Universiteit Gent
This is, to our knowledge, the first case report with in-depth analysis of bone marrow and bone lesions with diffusion-weighted imaging and dynamic contrast-enhanced MRI in Erdheim-Chester disease to date. We present a case of a 70-year-old woman who was referred for an X-ray of the pelvis, right femur and right knee after complaints of migratory arthralgia in hip and knee five months after an initial hip and knee trauma. Bone lesions on X-ray ...