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A pan-cancer single-cell tumor micro-environment atlas predictive of immunotherapy response KU Leuven
Effect of pembrolizumab on biomarkers related to intratumoral immunity, proliferation and apoptosis in early breast cancer KU Leuven
Up to thirty percent of patients with early breast cancer (BC) will eventually develop metastases. This results in an ongoing search for treatments to improve the long-term survival of these patients. Immune checkpoint inhibitors (ICI) are one promising type of therapeutic targets and have shown good results in malignancies as melanoma and non-small cell lung cancer. In BC, and especially in triple negative BC (TNBC), a clinical benefit for the ...
Comparison of the tumor immune microenvironment of primary hormone receptor-negative HER2-positive and triple negative breast cancer KU Leuven
The vast majority of studies investigating immune checkpoint inhibition (ICI) in patients with breast cancer have focused on triple-negative breast cancer (TNBC). In this study, we compared the tumor immune microenvironment (TIME) between TNBC and hormone receptor-negative HER2-positive breast cancer based on a selection of immune markers at the protein level in an institutional retrospective series. Additionally, we performed a similar ...
Blood Immunosenescence Signatures Reflecting Age, Frailty and Tumor Immune Infiltrate in Patients with Early Luminal Breast Cancer KU Leuven
BACKGROUND: Immune/senescence-related host factors play a pivotal role in numerous biological and pathological process like aging, frailty and cancer. The assessment of these host factors via robust, non-invasive, and easy-to-measure blood biomarkers could improve insights in these processes. Here, we investigated in a series of breast cancer patients in which way single circulating biomarkers or biomarker panels relate to chronological age, ...
Age‐related remodelling of the blood immunological portrait and the local tumor immune response in patients with luminal breast cancer KU Leuven
OBJECTIVES: Aging is associated with altered immune function and chronic low-grade inflammation, referred to as immunosenescence. As breast cancer is an age-related disease, the impact of aging on tumor immune responses may have important consequences. However, effects of immunosenescence on breast tumor immune infiltration remain largely unknown. METHODS: This exploratory study investigated a broad panel of immune/senescence markers in ...
Early drain removal improves quality of life and clinical outcomes in patients with breast cancer – Results from a randomised controlled trial KU Leuven
PURPOSE: The use of suction drains after breast cancer surgery (BCS) is common practice. However, the optimal time to remove drains is not clear yet and limited research has been conducted so far to assess the impact of their use on patient comfort. The goal of this study was to investigate the effect of early drain removal after BCS on quality of life (QoL) and clinical outcome. METHOD: A randomised controlled trial was conducted in 99 patients ...