Targeting long non-coding RNAs in cancer therapies KU Leuven
The class of long non-coding RNAs (lncRNAs) is a relatively recently discovered heterogeneous group of RNA molecules with an arbitrarily defined length of more than 200 nucleotides that are involved in multiple physiologic processes. Similar to mRNA, most of them are transcribed by RNA Polymerase II, spliced, capped and polyadenylated. In contrast with mRNA, their expression levels are much lower but show very tissue and cell type-specific ...