Physically asymmetric division of the C. elegans zygote ensures invariably successful embryogenesis KU Leuven
A paucigranulocytic asthma host environment promotes the emergence of virulent influenza viral variants KU Leuven
Current cancer driver variant predictors learn to recognize driver genes instead of functional variants KU Leuven
Antimicrobial resistance and COVID-19: intersections and implications Instituut voor Tropische Geneeskunde
Before the coronavirus 2019 (COVID-19) pandemic began, antimicrobial resistance (AMR) was among the top priorities for global public health. Already a complex challenge, AMR now needs to be addressed in a changing healthcare landscape. Here, we analyse how changes due to COVID-19 in terms of antimicrobial usage, infection prevention, and health systems affect the emergence, transmission, and burden of AMR. Increased hand hygiene, decreased ...
A structure of substrate-bound Synaptojanin1 provides new insights in its mechanism and the effect of disease mutations Vrije Universiteit Brussel
Synaptojanin1 (Synj1) is a phosphoinositide phosphatase, important in clathrin uncoating during endocytosis of presynaptic vesicles. It was identified as a potential drug target for Alzheimer's disease, Down syndrome, and TBC1D24-associated epilepsy, while also loss-of-function mutations in Synj1 are associated with epilepsy and Parkinson's disease. Despite its involvement in a range of disorders, structural, and detailed mechanistic ...
In vitro reconstitution of dynamically interacting integral membrane subunits of energy-coupling factor transporters Vrije Universiteit Brussel
Energy-coupling factor (ECF) transporters mediate import of micronutrients in prokaryotes. They consist of an integral membrane S-component (that binds substrate) and ECF module (that powers transport by ATP hydrolysis). It has been proposed that different S-components compete for docking onto the same ECF module, but a minimal liposome-reconstituted system, required to substantiate this idea, is lacking. Here, we co-reconstituted ECF ...