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Formalin-fixed paraffin-embedded tissue: The holy grail of clinical proteomics KU Leuven
Tissue is the most relevant biological material to gather insight in disease mechanisms by means of omics technologies. However, fresh frozen tissue, which is generally regarded as the best imaginable source for such studies, is often not available. In case it is available, the different ways of storage (e.g. -20°C, -80°C, liquid nitrogen, etc.) hamper the conduction of reproducible multicenter studies because of different protein degradation ...
Elucidating the Structure and Dynamics of Small Heat Shock Protein Complexes using a Hybrid Approach KU Leuven
Digital image correlation for full-field time-resolved assesment of arterial stiffness KU Leuven
Pulse wave velocity (PWV) of the arterial system is a very important parameter to evaluate cardiovascular health. Currently, however, there is no golden standard for PWV measurement. In this work, DIC was used for full-field time-resolved assessment of displacement, velocity, acceleration and strains of the skin in the neck directly above the common carotid artery (CCA).By assessing these parameters, propagation of the pulse wave could be ...
Proteomic analysis of formalin-fixed paraffin-embedded colorectal cancer tissue using tandem mass tag protein labeling KU Leuven
In clinical research, repositories of biological samples form a rich source of clinical material for biomarker studies. Banked material, however, is often not stored in optimal conditions regarding the technology used for biomarker research. A case in point is formalin-fixed paraffin-embedded (FFPE) tissue that could be used to obtain large cohorts of samples over a short period of time, as these tissues are routinely prepared for pathological ...
Personal distributed exposimeter for radio frequency exposure assessment in real environments KU Leuven
For the first time, a personal distributed exposimeter (PDE) for radio frequency (RF) measurements is presented. This PDE is designed based on numerical simulations and is experimentally evaluated using textile antennas and wearable electronics. A prototype of the PDE is calibrated in an anechoic chamber. Compared to conventional exposimeters, which only measure in one position on the body, an excellent isotropy of 0.5 dB (a factor of 1.1) and a ...