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News on infantile haemangioma. Part 1 Vrije Universiteit Brussel

Hannah De Leye, Julie Saerens, Sherief Janmohamed

Currently, there is no doubt that the first choice of treatment for alarming infantile haemangiomas (IHs) is oral beta-blockers. However, research in this field remains active, as the pathogenesis of IH is still not completely elucidated. Furthermore, there are different approaches to the management of IHs with beta-blockers. In Part 1 of this review we will discuss the state-of-the-art evidence for IH with regard to (i) the definition, ...

Management of penile cancer patients during the COVID-19 pandemic: An eUROGEN accelerated Delphi consensus study KU Leuven

Omer Onur Cakir, Fabio Castiglione, Zafer Tandogdu, Justin Collins, Hussain M Alnajjar, Clare Akers, Maarten Albersen, Constantine Alifrangis, Benjamin Ayres, Oscar Brouwer, et al.
OBJECTIVES: To develop an international consensus on managing penile cancer patients during the COVID-19 acute waves. A major concern for patients with penile cancer during the coronavirus disease 2019 (COVID-19) pandemic is how the enforced safety measures will affect their disease management. Delays in diagnosis and treatment initiation may have an impact on the extent of the primary lesion as well as the cancer-specific survival because of ...

C-reactive protein and neutrophil-lymphocyte ratio are prognostic in metastatic clear-cell renal cell carcinoma patients treated with nivolumab KU Leuven

Eduard Roussel, Lisa Kinget, A Verbiest, Pascal Debruyne, M Baldewijns, Hendrik Van Poppel, Maarten Albersen, B Beuselinck
Objective To evaluate the impact of markers of systemic inflammation such as C-reactive protein (CRP) and neutrophil-lymphocyte ratio (NLR) on outcomes of metastatic clear-cell renal cell carcinoma (m-ccRCC) patients treated with nivolumab. Patients and methods We retrospectively evaluated m-ccRCC patients treated with nivolumab and collected known prognostic factors and survival data. We used Kaplan-Meier survival analysis and cox proportional ...

Robot-assisted artificial urinary sphincter implantation KU Leuven

Benoit Peyronnet, Gary Gray, Gregoire Capon, Jean-Nicolas Cornu, Frank Van der Aa
PURPOSE OF REVIEW: The aim of the present manuscript was to provide an overview on the current state of robotic artificial urinary sphincter (AUS) implantation in male and female patients. RECENT FINDINGS: Over the past few years, several series have been reported, with promising outcomes for the most part. This has contributed to expand the use of bladder neck AUS, especially in female patients, which was, until then, hampered by its ...

Telemedicine and smart working: Spanish adaptation of the European Association of Urology recommendations. KU Leuven

J Gómez Rivas, A Rodríguez-Serrano, S Loeb, J Yuen-Chun Teoh, MJ Ribal, J Bloemberg, J Catto, J ŃDow, Hendrik Van Poppel, J González, et al.
INTRODUCTION: Telemedicine provides remote clinical support through technology tools. It can facilitate medical care delivery while reducing unnecessary office visits. The COVID-19 outbreak has caused an abrupt change in our daily urological practice, where teleconsultations play a crucial role. OBJECTIVE: To provide practical recommendations for the effective use of technological tools in telemedicine. MATERIALS AND METHODS: A literature search ...

Chronic Kidney Disease After Partial Nephrectomy in Patients With Preoperative Inconspicuous Renal Function - Curiosity or Relevant Issue? KU Leuven

Malin Nientiedt, Riccardo Bertolo, Riccardo Campi, Umberto Capitanio, Selcuk Erdem, Onder Kara, Tobias Klatte, Alessandro Larcher, Maria Carmen Mir, Idir Ouzaid, et al.
BACKGROUND: Chronic kidney disease (CKD) is a severe long-term complication after partial nephrectomy (PN). Clinical and scientific focus lies on patients with impaired renal function at the time of surgery. Little data is available on patients with normal preoperative renal function (NPRF). PATIENTS AND METHODS: Patients who underwent PN with a preoperative estimated glomular filtration rate > 60 mL/min/1.73m2 were retrospectively examined ...

Pushing the limits of metastasis-directed treatment in metastatic renal cell carcinoma in the era of targeted therapy KU Leuven

Serge Holz, Lorenzo Tosco, Murat Akand, Annelies Verbiest, Benoit Beuselinck, Maarten Albersen, Eduard Roussel, Hendrik Van Poppel, Steven Joniau
OBJECTIVE: To assess the role of metastasis directed therapy and in particular surgical metastasectomy (MxT) in metastatic renal cell carcinoma (mRCC) in the era of targeted therapy. METHOD: The files of all patients who underwent MxT for treatment of mRCC in University Hospitals Leuven between 1989 and 2015 were reviewed. RESULTS: One hundred and thirty eight patients met the inclusion criteria. Mean age at MxT was 59.3 (IQR: 57.5-61.0) years. ...

Low-Dose Enzalutamide in Late-Elderly Patients (≥ 75 Years Old) Presenting With Metastatic Castration-Resistant Prostate Cancer UZBrussel

Vincent Vinh - Hung, Gilles Natchagande, Clarisse Joachim, Olena Gorobets, Moustapha Dramé, Stefanos Bougas, Edmund Folefac, Nam P Nguyen, Claire Verschraegen, Ming Yin, et al.
Background: Enzalutamide, a major antiandrogen indicated for metastatic castration-resistant prostate cancer, has worrisome toxicities in aging patients. Dose reduction might limit toxicity, but potential loss of efficacy is a concern. We compare up-front low-dose versus standard-dose enzalutamide.Patients and methods: Records of prostate cancer patients receiving enzalutamide were retrospectively retrieved. Selection criteria were: age ≥ 75, ...

Patients' experiences of transitioning between different renal replacement therapy modalities: A qualitative study Vrije Universiteit Brussel

Els Holvoet, Sofie Verhaeghe, Simon Davies, Gill Combes, Karlien François, David Johnson, Wim Van Biesen, Liesbeth Van Humbeeck
Background:

Different kidney replacement therapy modalities are available to manage end-stage kidney disease, such as home-based dialysis, in-center hemodialysis, and kidney transplantation. Although transitioning between modalities is common, data on how patients experience these transitions are scarce. This study explores patients' perspectives of transitioning from a home-based to an in-center modality.

Methods:

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