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18F-FDG PET in Giant Cell Arteritis. KU Leuven

Niloefar Ahmadi Bidakhvidi, Karolien Goffin, Koenraad Van Laere, Olivier Gheysens, Daniel Blockmans
An 87-year-old man, without significant history, presented at the emergency department with recurrent episodes of fever and weight loss for several weeks without diagnosis, despite extensive routine investigations including conventional imaging. F-FDG PET/CT revealed strongly increased uptake in the peripheral vessels of the upper and lower limbs with relative sparing of the larger vessels. Temporal artery biopsy was positive for arteritis. The ...

Benefits of Using a Spatially-Variant Penalty Strength With Anatomical Priors in PET Reconstruction. KU Leuven

Yu-Jung Tsai, Georg Schramm, Sangtae Ahn, Alexandre Bousse, Simon Arridge, Johan Nuyts, Brian F Hutton, Charles W Stearns, Kris Thielemans
In this study, we explore the use of a spatially-variant penalty strength in penalized image reconstruction using anatomical priors to reduce the dependence of lesion contrast on surrounding activity and lesion location. This work builds on a previous method to make the local perturbation response (LPR) approximately spatially invariant. While the dependence of lesion contrast on the local properties introduced by the anatomical penalty is ...

Low septal to lateral wall 18F-FDG ratio is highly associated with mechanical dyssynchrony in non-ischemic CRT candidates. KU Leuven

Ganna Degtiarova, Piet Claus, Jürgen Duchenne, Marta Cvijic, Georg Schramm, Johan Nuyts, Jens-Uwe Voigt, Olivier Gheysens
BACKGROUND: In order to better understand the concept of mechanical dyssynchrony, a promising hallmark of cardiac resynchronization therapy (CRT) response, we investigated its effect on regional myocardial metabolism and myocardial blood flow (MBF) in non-ischemic CRT candidates. RESULTS: Thirty consecutive non-ischemic CRT eligible patients underwent static 18F-FDG and resting dynamic 13N-NH3 PET/CT. 18F-FDG uptake and MBF for septal and ...

Mechanism of Abnormal Septal Motion in Left Bundle Branch Block Role of Left Ventricular Wall Interactions and Myocardial Scar KU Leuven

John M Aalen, Espen W Remme, Camilla K Larsen, Oyvind S Andersen, Magnus Krogh, Jürgen Duchenne, Einar Hopp, Stian Ross, Ahmed S Beela, Erik Kongsgaard, et al.
OBJECTIVES: This study sought to investigate how regional left ventricular (LV) function modifies septal motion in left bundle branch block (LBBB). BACKGROUND: In LBBB, the interventricular septum often has marked pre-ejection shortening, followed by immediate relengthening (rebound stretch). This motion, often referred to as septal flash, is associated with positive response to cardiac resynchronization therapy (CRT). METHODS: In 10 ...

Ultrasound-Guided Extraction of Intrauterine Devices With Nonvisible Threads: 254 Consecutive Cases: An Effective, Noninvasive Technique KU Leuven

Cristian Kottmann, Maite Troncoso, Ignacio Valenzuela, Carolina Ugarte, Pilar Diaz, Max Monckeberg, Sebastian E Illanes
Intrauterine devices (IUDs) are among the most efficient and widely used contraceptive methods available. Removal is recommended after a certain time or in some cases when adverse effects are observed. A considerable number of patients have nonvisible guides or "lost threads" on speculum examinations, hindering the extraction. In this article, we report a consecutive series of 254 nonpregnant patients referred to our center after 1 or more ...

Super-resolution for upper abdominal MRI: Acquisition and post-processing protocol optimization using brain MRI control data and expert reader validation KU Leuven

Michael Ebner, Premal A Patel, David Atkinson, Lucy Caselton, Louisa Firmin, Zahir Amin, Alan Bainbridge, Paolo De Coppi, Stuart A Taylor, Sebastien Ourselin, et al.
PURPOSE: Magnetic resonance (MR) cholangiopancreatography (MRCP) is an established specialist method for imaging the upper abdomen and biliary/pancreatic ducts. Due to limitations of either MR image contrast or low through-plane resolution, patients may require further evaluation with contrast-enhanced computed tomography (CT) images. However, CT fails to offer the high tissue-ductal-vessel contrast-to-noise ratio available on T2-weighted MR ...

Clinical Translation of [68Ga]Ga-NOTA-anti-MMR-sdAb for PET/CT Imaging of Protumorigenic Macrophages Vrije Universiteit Brussel

Catarina Xavier, Anneleen Blykers, Damya Laoui, Evangelia Bolli, Ilse Vaneycken, Jessica Bridoux, Henri Vincent Baudhuin, Geert Raes, Hendrik Everaert, Kiavash Movahedi, et al.

PURPOSE: Macrophage mannose receptor (MMR, CD206) expressing tumor-associated macrophages (TAM) are protumorigenic and was reported to negatively impact therapy responsiveness and is associated with higher chances of tumor relapse following multiple treatment regimens in preclinical tumor models. Since the distribution of immune cells within the tumor is often heterogeneous, sampling "errors" using tissue biopsies will occur. In order to ...

Nanobody-Facilitated Multiparametric PET/MRI Phenotyping of Atherosclerosis Vrije Universiteit Brussel

Max L Senders, Sophie Hernot, Giuseppe Carlucci, Jan C van de Voort, Francois Fay, Claudia Calcagno, Jun Tang, Amr Alaarg, Yiming Zhao, Seigo Ishino, et al.

OBJECTIVES: This study sought to develop an integrative positron emission tomography (PET) with magnetic resonance imaging (MRI) procedure for accurate atherosclerotic plaque phenotyping, facilitated by clinically approved and nanobody radiotracers.

BACKGROUND: Noninvasive characterization of atherosclerosis remains a challenge in clinical practice. The limitations of current diagnostic methods demonstrate that, in addition to ...