In vivo structurele en functionele analyse van de atonal transcriptie factor. KU Leuven
The experiments proposed herein constitute the first time an extensive structure-function analysis in the endogenous locus has been carried out for a proneural genes. The very high efficiency with which we are able to replace the Atonal locus, means that generating the various necessary chimeras in the locus will be achieved with minimum effort. This allows us to focus most of our efforts on the functional analysis of these variants. We are ...