Titel Deelnemers "Telwoorden en kwantoren: syntaxis versus semantiek. Bespreking van hoofdstuk 6 “Numerals and quantifiers” in Syntax of Dutch: Nouns and Noun Phrases Volume 2 (Broekhuis & den Dikken, 2012)" "Hans Smessaert" "Site vs. core laboratory variability in computed tomographic angiography-derived SYNTAX scores in the SYNTAX III trial" "Yuki Katagiri, Daniele Andreini, Yosuke Miyazaki, Hidenori Komiyama, Saima Mushtaq, Jeroen Sonck, Danny Schoors, Francesco Maisano, Philipp A Kaufman, Ingrid Leal, Wietze Lindeboom, Jan Piek, Joanna J Wykrzykowska, Marie-angele Morel, Antonio L Bartorelli, Yoshinobu Onuma, Patrick W Serruys" "AIMS : To investigate the variability between site and core laboratory (CL) calculation of the anatomical SYNTAX score (SS) based on coronary computed tomography angiography (CTA) alone and functional SS based on coronary CTA and fractional flow reserve derived from computed tomography (FFRCT) in the SYNTAX III trial.METHODS AND RESULTS : The SYNTAX III trial was a multicentre, international study that included 223 patients with three-vessel disease with or without left main involvement. Functional SS was computed by subtracting non-flow limiting stenoses (FFRCT > 0.80) from anatomical SS. SS was combined with clinical information to generate the SYNTAX score II (SS II) that provides treatment recommendations. The mean anatomical SS based on coronary CTA alone was 33.4 ± 12.7 by sites and 37.1 ± 13.4 by CL (P " "Usefulness of updated logistic clinical SYNTAX score based on MI-SYNTAX score in patients with ST-elevation myocardial infarction" "Hideyuki Kawashima, Hironori Hara, Rutao Wang, Masafumi Ono, Chao Gao, Kuniaki Takahashi, Harry Suryapranata, Simon Walsh, James Cotton, Didier Carrie, Manel Sabate, Clemens Steinwender, Gregor Leibundgut, Joanna Wykrzykowska, Christian Hamm, Peter Juni, Pascal VRANCKX, Marco Valgimigli, Stephan Windecker, Robbert J. de Winter, Faisal Sharif, Yoshinobu Onuma, Patrick W. Serruys" "Objectives To compare the predictive performances of the prewiring, postwiring MI-SYNTAX scores, prewiring, and postwiring Updated Logistic Clinical SYNTAX score (LCSS) for 2-year all-cause mortality post percutaneous coronary intervention (PCI) in ST-elevation myocardial infarction (STEMI) patients. Background In patients with STEMI and undergoing primary PCI, coronary stenosis(es) distal to the culprit lesion is often observed after the restoration of coronary flow. To address comprehensively the complex coronary anatomy in these patients, prewiring and postwiring MI-SYNTAX scores have been reported in the literature. Furthermore, to enable individualized risk estimation for long-term all-cause mortality, the Updated LCSS has been developed by combining the anatomical SYNTAX score and clinical factors. Methods In the randomized GLOBAL LEADERS trial, anatomical SYNTAX score analysis was performed by an independent angiographic corelab for the first 4,000 consecutive patients as a prespecified analysis; of these, 545 presented with STEMI. The efficacy of the mortality predictions of the four scores at 2 years were evaluated based on their discrimination and calibration abilities. Results Complete data was available in 512 patients (93.9%). When the patients were stratified into two groups based on the median of the scores, the prewiring and postwiring Updated LCSSs demonstrated that the high-score groups were associated with higher rates of 2-year all-cause mortality compared to the low-score groups (6.6 vs. 1.2%; log-rank p = .001 and 6.6 vs. 1.2%; log-rank p = .001, respectively). There were no statistically significant differences for predicting the mortality between the prewiring (area under the curve [AUC] 0.625), postwiring MI-SYNTAX score (AUC 0.614), prewiring (AUC 0.755), and postwiring Updated LCSS (AUC 0.757). In the integrated discrimination improvement (IDI), the prewiring MI-SYNTAX score had a better discrimination for the mortality than the postwiring MI-SYNTAX score (IDI -0.0082; p = .029). The four scores had acceptable calibration abilities for 2-year all-cause mortality. Conclusions The prewiring Updated LCSS predicts long-term all-cause mortality with clearly useful discrimination and acceptable calibration. Since the postwiring MI-SYNTAX score does not improve mortality prediction, the prewiring MI-SYNTAX score may be preferred for the 2-year mortality prediction using the Updated LCSS." "Syntax and language disorders" "Martina Penke" "Appropriateness of the modality of revascularization according to the SYNTAX Score II 2020 in the FASTTRACK CABG study" "Kai Ninomiya, Patrick W Serruys, Nozomi Kotoku, Marie-angele Morel, Charles Taylor, John D Puskas, Jagat Narula, Ulrich Schneider, Torsten Doenst, Kaoru Tanaka, Johan De Mey, Mark La Meir, Saima Mushtaq, Antonio L Bartorelli, Giulio Pompilio, Daniele Andreini, Yoshinobu Onuma" "BACKGROUND: Personalized long term vital prognosis plays a key role in deciding between percutaneous coronary intervention (PCI) and CABG in patients with complex coronary artery disease. The FASTTRACK CABG trial enrolls patients with the sole guidance of coronary computed tomographic angiography (CCTA) and fractional flow reserve CCTA (FFRCT). The feasibility/non-feasibility of this approach is determined by the surgeon request to have access to the invasive coronary angiography.METHODS: This interim analysis, which was requested by the Data and Safety Monitoring Board (DSMB), compared the treatment decision of the ""on site"" Heart team to the recommended treatment as per the SYNTAX Score II 2020 (SS-2020), which was prospectively assessed by the central core laboratory in the first 57 consecutive patients (half of the planned population) enrolled in this First in Man study.RESULTS: The average anatomical SYTAX Score is 35.6 ± 11.5. The SS-2020 predicted 5-year MACE and 10-year all-cause mortality are 14.7 % and 21.6 % following CABG, and 23.0 % and 30.4 % following PCI. Among the enrolled patients the SS-2020 predicts long-term PCI outcomes similar to CABG (absolute risk difference ≤0 % in favor of PCI) in only two patients whilst the remaining 55 patients had a predicted survival benefit with CABG.CONCLUSIONS: According to the SS-2020, the first 57 patients recruited into the FASTTRACK CABG trial received the appropriate modality of revascularization and the DSMB allowed the investigators to complete the study." "The syntax of particles" "West Flemish V3 and the interaction of syntax and discourse" "Liliane Haegeman, Ciro Greco" "The origin and evolution of syntax errors in simple sequence flow models in BPMN" "Joshua De Bock, Jan Claes" "How do syntax errors emerge? What is the earliest moment that potential syntax errors can be detected? Which evolution do syntax errors go through during modeling? A provisional answer to these questions is formulated in this paper based on an investigation of a dataset containing the operational details of 126 modeling sessions. First, a list is composed of the different potential syntax errors. Second, a classification framework is built to categorize the errors according to their certainty and severity during modeling (i.e., in partial or complete models). Third, the origin and evolution of all syntax errors in the dataset are identified. This data is then used to collect a number of observations, which form a basis for future research." "The ability of computed tomography angiography to predict 5-year mortality in the SYNTAX III REVOLUTION trial" "Patrick W Serruys, Saima Mushtaq, Kaoru Tanaka, Damien Mandry, Ronny R Buechel, Franck Digne, Ulrich Schneider, Giulio Pompilio, Mark La Meir, Torsten Doenst, Ulf Teichgraber, Marie-angele Morel, Nozomi Kotoku, Kai Ninomiya, Neil O'Leary, Carlos Collet, Johan De Mey, Daniele Andreini, Yoshinobu Onuma" "BACKGROUND: The feasibility of using coronary computed tomography angiography (CCTA) for long-term prediction of vital prognosis post-revascularization remains unknown.OBJECTIVES: To compare the prognostic value of the SYNTAX score II 2020 (SS-2020) derived from invasive coronary angiography (ICA) or CCTA in patients with three-vessel disease and/or left main coronary artery disease undergoing percutaneous or surgical revascularization.METHODS: In the SYNTAX III REVOLUTION trial, the probability of death at five years was retrospectively assessed by calculating the SS-2020 using ICA and CCTA. High- and low-risk patients for mortality were categorized according to the median percentages of predicted mortality based on both modalities. The discriminative abilities of the SS-2020 were assessed using Harrell's C statistic.RESULTS: The vital status at five years of the 215 patients revascularized percutaneously (64 patients, 29.8%) or surgically (151 patients, 70.2%) was established through national registries. In patients undergoing revascularization, the SS-2020 was possibly helpful in discriminating vital prognosis at 5 years, with similar results seen with ICA and CCTA (C-index with ICA ​= ​0.75, intercept ​= ​-0.19, slope ​= ​0.92 and C-index with CCTA ​= ​0.75, intercept ​= ​-0.22, slope ​= ​0.99). In high- and low-risk patients, Kaplan-Meier estimates showed significant, and almost identical relative differences in observed mortality, irrespective of imaging modality (ICA: 93.8% vs 78.7%, log-lank P ​< ​0.001; CCTA: 93.7% vs 78.5%, log-lank P ​< ​0.001).CONCLUSIONS: The predictive ability of the SS-2020 for five-year all-cause mortality derived from ICA and CCTA was comparable, and could helpfully discriminate vital prognosis in high- and low-risk patients." "Feasibility of planning coronary artery bypass grafting based only on coronary computed tomography angiography and CT-derived fractional flow reserve: a pilot survey of the surgeons involved in the randomized SYNTAX III Revolution trial" "Jeroen Sonck, Yosuke Miyazaki, Carlos Collet, Yoshinobu Onuma, Taku Asano, Yuki Katagiri, Rodrigo Modolo, Patrick W Serruys, Antonio L Bartorelli, Daniele Andreini, Torsten Doenst, Juan Pablo Maureira, Mark La Meir" "Abstract OBJECTIVES: Invasive coronary angiography has been the preferred diagnostic method to guide the decision-making process between coronary artery bypass grafting (CABG) and percutaneous coronary intervention and plan a surgical revascularization procedure. Guidelines recommend a heart team approach and assessment of coronary artery disease (CAD) complexity, objectively quantified by the anatomical SYNTAX score. Coronary computed tomography angiography (CCTA) and CT-derived fractional flow reserve (FFRCT) are emerging technologies in the diagnosis of stable CAD. In this study, data from patients with left main or 3-vessel CAD who underwent CABG were evaluated to assess the feasibility of developing a surgical plan based on CCTA integrated with FFRCT. The primary objective was to assess the theoretical feasibility of surgical decision-making and treatment planning based only on non-invasive imaging. METHODS: This study represents a survey of surgeons involved in the SYNTAX III Revolution trial. In this trial, heart teams were randomized to make treatment decisions using CTA. CCTAs and FFRCT results of 20 patients were presented to 5 cardiac surgeons. RESULTS: Surgical treatment decision-making based on CCTA with FFRCT was considered feasible by a panel of surgeons in 84% of the cases with an excellent agreement on the number of anastomoses to be made in each patient (intraclass correlation coefficient 0.77, 95% confidence interval 0.35-0.96). CONCLUSIONS: Using non-invasive imaging only in patients with left main or 3-vessel CAD, an excellent agreement on treatment planning and the number of anastomoses was found among cardiac surgeons. Thus, CABG planning based on non-invasive imaging appears feasible. Further investigation is warranted to determine the safety and feasibility in clinical practice."