Titel Deelnemers "Korte inhoud" "Cost-utility analysis of Dexcom G6 real-time continuous glucose monitoring versus FreeStyle Libre 1 intermittently scanned continuous glucose monitoring in adults with type 1 diabetes in Belgium" "Margaretha M. Visser, Astrid Van Muylder, Sara Charleer, John J. Isitt, Stephane Roze, Christophe De Block, Toon Maes, Gerd Vanhaverbeke, Frank Nobels, Bart Keymeulen, Chantal Mathieu, Jeroen Luyten, Pieter Gillard, Nick Verhaeghe" "Aims/hypothesisThe aim of this study was to assess the long-term cost-effectiveness of Dexcom G6 real-time continuous glucose monitoring (rtCGM) with alert functionality compared with FreeStyle Libre 1 intermittently scanned continuous glucose monitoring (isCGM) without alerts in adults with type 1 diabetes in Belgium.MethodsThe IQVIA CORE Diabetes Model was used to estimate cost-effectiveness. Input data for the simulated baseline cohort were sourced from the randomised ALERTT1 trial (ClinicalTrials.gov. registration no. NCT03772600). The age of the participants was 42.9 +/- 14.1 years (mean +/- SD), and the baseline HbA1c was 57.8 +/- 9.5 mmol/mol (7.4 +/- 0.9%). Participants using rtCGM showed a reduction in HbA1c of 3.6 mmol/mol (0.36 percentage points) based on the 6-month mean between-group difference. In the base case, both rtCGM and isCGM were priced at euro3.92/day (excluding value-added tax [VAT]) according to the Belgian reimbursement system. The analysis was performed from a Belgian healthcare payer perspective over a lifetime time horizon. Health outcomes were expressed as quality-adjusted life years. Probabilistic and one-way sensitivity analyses were used to account for parameter uncertainty.ResultsIn the base case, rtCGM dominated isCGM, resulting in lower diabetes-related complication costs and better health outcomes. The associated main drivers favouring rtCGM were lower HbA1c, fewer severe hypoglycaemic events and reduced fear of hypoglycaemia. The results were robust under a wide range of one-way sensitivity analyses. In models where the price of rtCGM is euro5.11/day (a price increase of 30.4%) or euro12.34/day (a price increase of 214.8%), rtCGM was cost-neutral or reached an incremental cost-effectiveness ratio of euro40,000 per quality-adjusted life year, respectively.Conclusions/interpretationWhen priced similarly, Dexcom G6 rtCGM with alert functionality has both economic and clinical benefits compared with FreeStyle Libre 1 isCGM without alerts in adults with type 1 diabetes in Belgium, and appears to be a cost-effective glucose monitoring modality.Trial registration ClinicalTrials.gov NCT03772600Conclusions/interpretationWhen priced similarly, Dexcom G6 rtCGM with alert functionality has both economic and clinical benefits compared with FreeStyle Libre 1 isCGM without alerts in adults with type 1 diabetes in Belgium, and appears to be a cost-effective glucose monitoring modality.Trial registration ClinicalTrials.gov NCT03772600" "The Development of a Non-Invasive Monitoring System for Real-Time Monitoring and Prediction of Cell Behavior in Vitro" "S Viazzi, T Lambrechts, Inge Holsbeeks, I Papantoniou, J Aerts, V Bloemen" "Mach-Zehnder Interferometer for Real-Time In Situ Monitoring of Refractive Microlens Characteristics at the Fabrication Level" "Virginia Gomez Onate" "We present a Mach-Zehnder interferometer to monitor in situ and in real-time the geometrical and optical characteristics of refractive microlenses during their fabrication process to increase the fabrication, accuracy as well as the sample-to-sample reproducibility. We demonstrate for one test case that the deviation of our developed interferometric system against commercial instrumentation is smaller than 5% while its repeatability error is smaller than 1.5% after calibration against dedicated off-line instrumentation. To conclude, we demonstrate the practical usefulness of this interferometer by applying it to the fabrication of microlenses; by deep proton writing." "MiCLAD as a platform for real-time monitoring and machine learning in laser metal deposition" "Patrick Guillaume, Jan Helsen" "The MiCLAD machine designed at the VUB, Belgium, allows for closed-loop controlled laser metal deposition including various in-situ optical based measurement systems. These integrated sensors collect information on deposition geometry and temperature during the building process. Hence, each cubic millimeter of material that is either added or removed is mapped to its digital twin with a millisecond temporal resolution in the machines database. This paper introduces the platform and its capabilities by focusing on the procedure of obtaining the necessary training data for the future application of machine learning algorithms, with the goal of controlling the geometry and temperature history during additive manufacturing." "Off-axis high-speed camera-based real-time monitoring and simulation study for laser powder bed fusion of 316L stainless steel" "Aditi Thanki, Carlos Josué Jordán Martínez, Brian Booth, Dries Verhees, Rob Heylen, Mariam Mir, Abdellatif Bey-Temsamani, Wilfried Philips, Ann Witvrouw, Han Haitjema" "Real-time monitoring of forward osmosis membrane fouling in wastewater reuse process performed with a deep learning model" "Sung Ju Im, Viet Nguyen Duc, Am Jang" "Networking the forest infrastructure towards near real-time monitoring : a white paper" "Roman Zweifel, Christoforos Pappas, Richard L. Peters, Flurin Babst, Daniel Balanzategui, David Basler, Ana Bastos, Mirela Beloiu, Nina Buchmann, Arun K. Bose, Sabine Braun, Alexander Damm, Petra D'Odorico, Jan U. H. Eitel, Sophia Etzold, Patrick Fonti, Elham Rouholahnejad Freund, Arthur Gessler, Matthias Haeni, Guenter Hoch, Ansgar Kahmen, Christian Korner, Jan Krejza, Frank Krumm, Michael Leuchner, Christoph Leuschner, Mirko Lukovic, Jordi Martinez-Vilalta, Radim Matula, Henning Meesenburg, Patrick Meir, Roman Plichta, Rafael Poyatos, Brigitte Rohner, Nadine Ruehr, Roberto Luis Salomon Moreno, Tobias Scharnweber, Marcus Schaub, David N. Steger, Christopher Still, Marko Stojanovic, Volodymyr Trotsiuk, Yann Vitasse, Georg von Arx, Martin Wilmking, Cedric Zahnd, Frank Sterck" "Qualification of an Ultrasonic Instrument for Real-Time Monitoring of Size and Concentration of Nanoparticles during Liquid Phase Bottom-Up Synthesis" "Gert Jan van Groenestijn, Nicole Meulendijks, Renz van Ee, Arno Volker, Paul van Neer, Pascal BUSKENS, Cedric Julien, Marcel Verheijen" "Both in design and production of nanoparticles and nanocomposites it is of vital importance to have information about their size and concentration. During the formation of nanoparticles, real-time monitoring of particle size and concentration during bottom-up synthesis in liquids allows for a detailed study of nucleation and growth. This provides valuable insights into the formation of nanoparticles that can be used for process optimization and scale up. In the production of nanoparticles, real-time monitoring enables intervention to minimize the number of off-spec batches. In this paper we will qualify an ultrasound nanoparticle sizer (UNPS) as a real-time monitor for the growth of nanoparticles (or sub-micro particles) in the 100 nm(-1) mu m range. Nanoparticles affect the speed and attenuation of ultrasonic waves in the dispersion. The size of the change depends, amongst other things, on the size and concentration of the nanoparticles. This dependency is used in the UNPS method. The qualification of the UNPS was undertaken in two successful experiments. The first experiment consisted of static measurements on commercially available silica particles, and the second experiment was real-time monitoring of the size and concentration during the growth of silica nanoparticles in Stober synthesis in a water-alcohol mixture starting from the molecular precursor tetraethyl orthosilicate. The results of the UNPS were verified by measurements of a dynamic light scattering device and a transmission electron microscope." "Flow Cell Coupled Dynamic Light Scattering for Real-Time Monitoring of Nanoparticle Size during Liquid Phase Bottom-Up Synthesis" "Nicole Meulendijks, Renz van Ee, Ralph Stevens, Maurice Mourad, Marcel Verheijen, Nils Kambly, Ricardo Armenta, Pascal BUSKENS" "To tailor the properties of nanoparticles and nanocomposites, precise control over particle size is of vital importance. Real-time monitoring of particle size during bottom-up synthesis in liquids would allow a detailed study of particle nucleation and growth, which provides valuable insights in the mechanism of formation of the nanoparticles. Furthermore, it facilitates a rational scale-up, and would enable adequate intervention in the production process of nanoparticle dispersions to minimize the number of off-spec batches. Since real-time monitoring requires particle size measurements on dispersions in flow, conventional dynamic light scattering (DLS) techniques are not suited: they rely on single scattering and measure the Brownian motion of particles dispersed in a liquid. Here, we present a set-up that allows accurate measurements in real-time on flowing dispersions using a DLS technique based on modulated 3D cross-correlation. This technique uses two simultaneous light scattering experiments performed at the same scattering vector on the same sample volume in order to extract only the single scattering information common to both. We connected the reactor to a flow-cell in the DLS equipment using a tailor-made analysis loop, and successfully demonstrated the complete set-up through monitoring of the size of spherical silica nanoparticles during Stober synthesis in a water-alcohol mixture starting from the molecular precursor tetraethyl orthosilicate." "Fully integrated flexible dielectric monitoring sensor system for real-time in situ prediction of the degree of cure and glass transition temperature of an epoxy resin" "Yang Yang, Bart Plovie, Gabriele Chiesura, Thomas Vervust, Lode Daelemans, Diana-Elena Mogosanu, Pieter Wuytens, Karen De Clerck, Jan Vanfleteren" "Flexible dielectric sensors received significant interest for real-time in situ cure monitoring of polymeric composites over the past decade. Currently, the state-of-the-art dielectric sensors mainly focus on detecting the distinct stages of the polymeric composite curing process. While low-cost and quantitative monitoring of the thermal, mechanical, and chemical properties of the materials during the cure is of great interest, to date, such a sensor system has not been realized because the existing devices excessively depend on external instrumentations, combined with a lack of an embedded reliable data processing module. Here, a fully integrated dielectric monitoring sensor system (DMS) incorporating dielectric and temperature sensors is developed, capable of monitoring in real-time the temperature, the degree of cure, and the glass transition temperature (T-g) of polymeric composites. An independent characterization of the cure kinetics was performed using differential scanning calorimetry and Raman spectroscopy. These data enabled associating the main physical and chemical transformations in the polymeric materials with particular features observed in the dielectric measurements. We demonstrate the accurate estimation of the degree of cure and T-g of an epoxy resin. The proposed system shows the potential for a new generation of intelligent manufacturing technology of composite materials."