Titel Deelnemers "Korte inhoud" "Serial Multimodality Imaging and 2-Year Clinical Outcomes of the Novel DESolve Novolimus-Eluting Bioresorbable Coronary Scaffold System for the Treatment of Single De Novo Coronary Lesions" "Alexandre Abizaid, Ricardo A Costa, Joachim Schofer, John A. Ormiston, Michael Maeng, Bernhard Witzenbichler, Roberto V. Botelho, J., Jr. Ribamar Costa, Daniel Chamie, Andrea S. Abizaid, Juliana P. Castro, Lynn Morrison, Sara Toyloy, Vinayak Bhat, John Yan, Stefan Verheye" "OBJECTIVES This study sought to report the late multimodality imaging and clinical outcomes of the novel poly-L-lactic-acid-based DESolve novolimus-eluting bioresorbable coronary scaffold for the treatment of de novo coronary lesions. BACKGROUND Bioresorbable scaffolds are an alternative to drug-eluting metallic stents and provide temporary vascular scaffolding, which potentially may allow vessel restoration and reduce the risk of future adverse events. METHODS Overall, 126 patients were enrolled at 13 international sites between November 2011 and June 2012. The primary endpoint was in-scaffold late lumen loss at 6 months. Major adverse cardiac events, the main safety endpoint, were defined as the composite of cardiac death, target vessel myocardial infarction, or clinically indicated target lesion revascularization. All patients underwent angiography at 6 months. Serial intravascular ultrasound and optical coherence tomography were performed in a subset of patients. RESULTS The scaffold device success rate was 97% (n = 122 of 126), and procedural success was 100% (n = 122 of 122). The major adverse cardiac event rate was 3.3% (n = 4 of 122) at 6 months and 7.4% (n = 9 of 122) at 24 months, including 1 probable stent thrombosis within the first month. At 6-month angiographic follow-up, in-scaffold late lumen loss was 0.20 +/- 0.32 mm. Paired intravascular ultrasound analysis demonstrated a significant increase in vessel, lumen and scaffold dimensions between post-procedure and 6-month follow-up, and strut-level optical coherence tomography analysis showed full strut coverage in 99 +/- 1.7%. CONCLUSIONS Our results showed favorable performance of the DESolve scaffold, effective inhibition of neointimal hyperplasia, and for the first time, early luminal and scaffold growth at 6 months with sustained efficacy and safety through 2 years. (Elixir Medical Clinical Evaluation of the DESolve Novolimus Eluting Bioresorbable Coronary Scaffold System-The DESolve Nx Trial; NCT02086045) (J Am Coll Cardiol Intv 2016;9:565-74) (C) 2016 by the American College of Cardiology Foundation." "Role of multimodality cardiac imaging in the management of patients with hypertrophic cardiomyopathy: an expert consensus of the European Association of Cardiovascular Imaging Endorsed by the Saudi Heart Association" "Sven Plein, Antonello D'Andrea, Oliver Bruder, Laurent Davin, Antonio Freitas, Gilbert Habib, Anastasia Kitsiou, Stephen Schroeder" "Taking into account the complexity and limitations of clinical assessment in hypertrophic cardiomyopathy (HCM), imaging techniques play an essential role in the evaluation of patients with this disease. Thus, in HCM patients, imaging provides solutions for most clinical needs, from diagnosis to prognosis and risk stratification, from anatomical and functional assessment to ischaemia detection, from metabolic evaluation to monitoring of treatment modalities, from staging and clinical profiles to follow-up, and from family screening and preclinical diagnosis to differential diagnosis. Accordingly, a multimodality imaging (MMI) approach (including echocardiography, cardiac magnetic resonance, cardiac computed tomography, and cardiac nuclear imaging) is encouraged in the assessment of these patients. The choice of which technique to use should be based on a broad perspective and expert knowledge of what each technique has to offer, including its specific advantages and disadvantages. Experts in different imaging techniques should collaborate and the different methods should be seen as complementary, not as competitors. Each test must be selected in an integrated and rational way in order to provide clear answers to specific clinical questions and problems, trying to avoid redundant and duplicated information, taking into account its availability, benefits, risks, and cost." "Multimodality imaging in takotsubo syndrome" "Rodolfo Citro, Hiroyuki Okura, Jelena R Ghadri, Chisato Izumi, Patrick Meimoun, Masaki Izumo, Dana Dawson, Shuichiro Kaji, Ingo Eitel, Nobuyuki Kagiyama, Yukari Kobayashi, Christian Templin, Satoshi Nakatani" "Takotsubo syndrome (TTS) is a complex and still poorly recognized heart disease with a wide spectrum of possible clinical presentations. Despite its reversibility, it is associated with serious adverse in-hospital events and high complication rates during follow-up. Multimodality imaging is helpful for establishing the diagnosis, guiding therapy, and stratifying prognosis of TTS patients in both the acute and post-acute phase. Echocardiography plays a key role, particularly in the acute care setting, allowing for the assessment of left ventricular (LV) systolic and diastolic function and the identification of the typical apical-midventricular ballooning pattern, as well as the circumferential pattern of wall motion abnormalities. It is also useful in the early detection of complications (i.e. LV outflow tract obstruction, mitral regurgitation, right ventricular involvement, LV thrombi, and pericardial effusion) and monitoring of systolic function recovery. Left ventriculography allows the evaluation of LV function and morphology, identifying the typical TTS patterns when echocardiography is not available or wall motion abnormalities cannot be properly assessed with ultrasound. Cardiac magnetic resonance provides a more comprehensive depiction of cardiac morphology and function and tissue characterization and offers additional value to other imaging modalities for differential diagnosis (myocardial infarction and myocarditis). Coronary computed tomography angiography has a substantial role in the diagnostic workup of patients with acute chest pain and a doubtful TTS diagnosis to rule out other medical conditions. It can be considered as a non-invasive appropriate alternative to coronary angiography in several clinical scenarios. Although the role of nuclear imaging in TTS has not yet been well established, the combination of perfusion and metabolic imaging may provide useful information on myocardial function in both the acute and post-acute phase." "Multimodality 3D image fusion with live fluoroscopy reduces radiation dose during catheterization of congenital heart defects" "Dimitri Buytaert, Kristof Vandekerckhove, Joseph Panzer, Laurence Campens, Klaus Bacher, Daniël De Wolf" "Introduction: Imaging fusion technology is promising as it is radiation and contrast sparing. Herein, we compare conventional biplane angiography to multimodality image fusion with live fluoroscopy using two-dimensional (2D)–three-dimensional (3D) registration (MMIF2D−3D) and assess MMIF2D−3D impact on radiation exposure and contrast volume during cardiac catheterization of patients with congenital heart disease (CHD). Methods: We matched institutional MMIF2D−3D procedures and controls according to patient characteristics (body mass index, age, and gender) and the seven procedure-type subgroups. Then, we matched the number of tests and controls per subgroup using chronological ordering or propensity score matching. Subsequently, we combined the matched subgroups into larger subgroups of similar procedure type, keeping subgroups with at least 10 test and 10 control cases. Air kerma (AK) and dose area product (DAP) were normalized by body weight (BW), product of body weight and fluoroscopy time (BW × FT), or product of body weight and number of frames (BW × FR), and stratified by acquisition plane and irradiation event type (fluoroscopy or acquisition). Three senior interventionists evaluated the relevance of MMIF2D−3D (5-point Likert scale). Results: The Overall group consisted of 54 MMIF2D−3D cases. The combined and matched subgroups were pulmonary artery stenting (StentPUL), aorta angioplasty (PlastyAO), pulmonary artery angioplasty (PlastyPUL), or a combination of the latter two (Plasty). The FT of the lateral plane reduced significantly by 69.6% for the Overall MMIF2D−3D population. AKBW and DAPBW decreased, respectively, by 43.9% and 39.3% (Overall group), 49.3% and 54.9% (PlastyAO), and 36.7% and 44.4% for the Plasty subgroup. All the aforementioned reductions were statistically significant except for DAPBW in the Overall and Plasty (sub)groups. The decrease of AKBW and DAPBW in the StentPUL and PlastyPUL subgroups was not statistically significant. The decrease in the median values of the weight-normalized contrast volume (CMCBW) in all five subgroups was not significant. Cardiologists considered MMIF2D−3D very useful with a median score of 4. Conclusion: In our institution, MMIF2D−3D overall enabled significant AKBW reduction during the catheterization of CHD patients and was mainly driven by reduced FT in the lateral plane. We observed significant AKBW reduction in the Plasty and PlastyAO subgroups and DAPBW reduction in the PlastyAO subgroup. However, the decrease in CMCBW was not significant." "Position paper of the EACVI and EANM on artificial intelligence applications in multimodality cardiovascular imaging using SPECT/CT, PET/CT, and cardiac CT" "Riemer H. J. A. Slart, Michelle C Williams, Luis Eduardo Juarez-Orozco, Christoph Rischpler, Marc R. Dweck, Andor W J M Glaudemans, Panagiotis Georgoulias, Olivier Gheysens, Oliver Gaemperli, Gilbert Habib, Roland Hustinx, Bernard Cosyns, Hein J Verberne, Fabien Hyafil, Paola Anna Erba, Mark Lubberink, Piotr Slomka, Ivana Išgum, Dimitris Visvikis, Márton Kolossváry, Antti Saraste" "In daily clinical practice, clinicians integrate available data to ascertain the diagnostic and prognostic probability of a disease or clinical outcome for their patients. For patients with suspected or known cardiovascular disease, several anatomical and functional imaging techniques are commonly performed to aid this endeavor, including coronary computed tomography angiography (CCTA) and nuclear cardiology imaging. Continuous improvement in positron emission tomography (PET), single-photon emission computed tomography (SPECT), and CT hardware and software has resulted in improved diagnostic performance and wide implementation of these imaging techniques in daily clinical practice. However, the human ability to interpret, quantify, and integrate these data sets is limited. The identification of novel markers and application of machine learning (ML) algorithms, including deep learning (DL) to cardiovascular imaging techniques will further improve diagnosis and prognostication for patients with cardiovascular diseases. The goal of this position paper of the European Association of Nuclear Medicine (EANM) and the European Association of Cardiovascular Imaging (EACVI) is to provide an overview of the general concepts behind modern machine learning-based artificial intelligence, highlights currently prefered methods, practices, and computational models, and proposes new strategies to support the clinical application of ML in the field of cardiovascular imaging using nuclear cardiology (hybrid) and CT techniques." "Multimodality and Decision-Making in Subtitling" "Tom Vanallemeersch, Tom Vanallemeersch" "Tumor recurrence and in-field control after multimodality treatment of locally advanced esophageal cancer" "Hendrik Thoen, Wim Ceelen, ELKE VAN DAELE" "Multilingualism, multimodality and identity construction on French-based amazigh (Berber) websites" "Mena Lafkioui" "PET-MRI: a review of challenges and solutions in the development of integrated multimodality imaging" "Stefaan Vandenberghe, Paul K Marsden" "Perceived car dependence and multimodality in urban areas in Flanders (Belgium)" "Eva Van Eenoo, Koos Fransen, Kobe Boussauw" "In this study, we test the extent to which people who reside in hypothetically car-independent neighbourhoods travel multimodally and perceive themselves as car dependent. We used the Flemish region as our study case, and defined a car-independent neighbourhood as an area with a high node and a high place value. A cluster analysis with four constituent variables – car use frequency, bicycle use frequency, vehicle kilometers travelled (VKT) and the need for a car to carry out daily activities - led to defining four heterogeneous groups of car owners. We labelled the groups as car-dependent motorists - long distance, car-dependent motorists - short distance, car-independent cyclists and car-dependent cyclists. We found all clusters to be to some extent multimodal. For our selected study area, car ownership does not necessarily induce perceived car-dependence among people who can easily get around by bicycle. Nevertheless, even in an urban setting and when exhibiting multimodal travel patterns, people can perceive their car as indispensable. Perceived car dependence is not necessarily correlated with high VKT or high frequency of car use, neither can we conclude that multimodal behaviour necessarily leads to less VKT."