Titel Participants Inhoud "Open Linguistic Picture Database" "Lise Paesen" "This dataset includes 101 pictures that belong to the Open Linguistic Picture Database." "CSV files and R script : writing process data of typed picture description by 15 cognitively impaired patients and 15 healthy controls" "Sven De Maeyer, Luuk Van Waes, Mariëlle Leijten, Sebastiaan Engelborghs" "No abstract available" "CSV file, R script and walk-through : pause data of a typed sentence production task by 116 adults" "Sven De Maeyer, Mariëlle Leijten" "Writing process data of 116 participants (50 - 90 years) were obtained. Each of them completed a typed sentence production task that consisted of 40 trials. Pause times between and within all words, target nouns and target verbs were logged with a keystroke logging tool (ScriptLog). The data were used to perform a Generalizability and a Decision study to determine the minimum number of trials and of items per trial that are necessary to generalize over tasks. This dataset contains the data that remained after eliminating the trials during which participants made deletions and corrections. The ..." "F-PACK whole-blood RNAseq counts" "Isabelle Cleynen" "This dataset contains the count data derived from bulk RNA sequencing of whole-blood RNA PAXgene samples. The cohort of individuals from which this sequencing data is derived is the Flemish Prevent Alzheimer's Disease Cohort KU Leuven (F-PACK)." "Messar: Automated Recommendation Of Metabolite Substructures From Tandem Mass Spectra" "Dirk VALKENBORG" "Data set associated with: Mrzic, A. et al. MESSAR: Automated recommendation of metabolite substructures from tandem mass spectra. bioRxiv (2017). doi:10.1101/134189 This data set is provided by Janssen Pharmaceutica. It consists of known standard pharmaceutical compounds for which high quality Q-Exactive MS/MS data is provided. The data set contain drugs ranging from antifungal and antipsychotic agents to inhibitors of the hepatitis C virus and a compound that slows down progression of Alzheimer's disease." "The Leuven-Haifa High-Resolution Fundus Image Dataset for Retinal Blood Vessel Segmentation and Glaucoma Diagnosis" "Jan Van Eijgen, Eirini Christinaki, Ingeborg Stalmans" "The Leuven-Haifa dataset contains 240 disc-centered fundus images of 224 unique patients (75 patients with normal tension glaucoma, 63 patients with high tension glaucoma, 30 patients with other eye diseases and 56 healthy controls) from the University Hospitals of Leuven. The arterioles and venules of these images were both annotated by master students in medicine and corrected by a senior annotator. All corrected segmentations are provided. Diagnosis, age, sex, vascular parameters as well as a quality score are provided as metadata. Potential reuse is envisioned as the development and ..." "CSV files, R script and stimuli : writing process data of typed intransitive, monotransitive and ditransitive sentences by 90 healthy adults" "Sven De Maeyer, Mariëlle Leijten" "Writing process data of 90 healthy elderly (50 - 90 years) were obtained. Each of them completed a typed sentence production task that consisted of 40 trials. Time on task, production time, and pause times before sentences, between words and within words were logged with a keystroke logging tool (ScriptLog). The data were used to examine the influences of normal ageing and verb transitivity on sentence production. The underlying aim was to provide a foundation for further research on sentence production in Alzheimer's disease (AD). This dataset contains the data that remained after ..." "Crystal structure of the 5-phosphatase domain of Synaptojanin1 in complex with a nanobody" "Jone Paesmans, Wim Versées, Christian Galicia Diaz Santana, Ella Martin" "Synaptojanin1 (Synj1) is a phosphoinositide phosphatase, important in clathrin uncoating during endocytosis of presynaptic vesicles. It was identified as a potential drug target for Alzheimer's disease, Down syndrome, and TBC1D24-associated epilepsy, while also loss-of-function mutations in Synj1 are associated with epilepsy and Parkinson's disease. Despite its involvement in a range of disorders, structural, and detailed mechanistic information regarding the enzyme is lacking. Here, we report the crystal structure of the 5-phosphatase domain of Synj1. Moreover, we also present a structure of ..." "Crystal structure of the 5-phosphatase domain of Synaptojanin1 bound to its substrate diC8-PI(3,4,5)P3 in complex with a nanobody." "Jone Paesmans, Wim Versées, Christian Galicia Diaz Santana, Ella Martin" "Synaptojanin1 (Synj1) is a phosphoinositide phosphatase, important in clathrin uncoating during endocytosis of presynaptic vesicles. It was identified as a potential drug target for Alzheimer's disease, Down syndrome, and TBC1D24-associated epilepsy, while also loss-of-function mutations in Synj1 are associated with epilepsy and Parkinson's disease. Despite its involvement in a range of disorders, structural, and detailed mechanistic information regarding the enzyme is lacking. Here, we report the crystal structure of the 5-phosphatase domain of Synj1. Moreover, we also present a structure of ..." "MESSAR: Automated recommendation of metabolite substructures from tandem mass spectra" "Thomas De Vijlder, Dirk Valkenborg, Pieter Meysman, Aida Ligata (Mrzic), Edwin P. Romijn" "This data set is provided by Janssen Pharmaceutica. It consists of known standard pharmaceutical compounds for which high quality Q-Exactive MS/MS data is provided. The data set contain drugs ranging from antifungal and antipsychotic agents to inhibitors of the hepatitis C virus and a compound that slows down progression of Alzheimer's disease."