Titel Deelnemers "Korte inhoud" "Early life jumping traits : are they good proxies for success in show jumping competitions in Belgian warmblood horses?" "Lea Chapard, Roel Meyermans, Wim Gorssen, Katrijn Hooyberghs, Inge Meurrens, Stefaan De Smet, Nadine Buys, Steven Janssens" "The main goal of the Belgian Warmblood horse studbook (BWP) is to breed successful competition horses, with emphasis on show jumping. However, competition results are only available later in life and competition traits are lowly heritable. Hence, the use of phenotypes that record performance-related traits at an early life stage could help increase genetic progress. In this study, we evaluated the potential of eleven linear scored early life jumping traits assessed during jumping in freedom (2-5 years old) or under the saddle (4-6 years old) as proxies for later success in show jumping competitions. To this end, we estimated their heritabilities and genetic correlations with the competition trait, adjusted fence height, by using 2170 free jumping records, 1588 jumping under saddle records, 674,527 show jumping competition records and almost 81,000 informative horses in the pedigree. As participation of young horses in these contests is on a voluntary basis, a pre-selection most probably exists. To verify this hypothesis, we investigated the association between participation to young horse contests and participation to show jumping competitions later on (called here start status phenotype). We also estimated heritabilities for ""start status in free jumping contest"", ""start status in jumping under saddle contest"" and ""start status in free jumping or jumping under saddle contest"" by fitting threshold models. Furthermore, we calculated genetic correlations between these traits and adjusted fence height and calculated the correlations between EBVs for start status in young horse contests and EBVs for success in competitions. Estimated heritabilities of early life jumping traits ranged between 0.05 and 0.30. Their genetic correlations with adjusted fence height were moderate to high (r(g) = 0.37-0.63). Relatively more horses that participated in young horse contests competed later on compared to horses that did not participate in young horse contests (p-value < 0.001). They were also significantly more successful in show jumping competitions. Furthermore, start status in young horse contests was moderately heritable in BWP horses (h(2) = 0.56-0.65) and moderately to highly correlated with later success in competitions (r(g) = 0.30-0.77). Hence, we showed that ELJ traits are good proxies for later success in competitions and that a pre-selection of horses occurs in young horse contests. It is suggested to stimulate participation to young horse contests to achieve a more representative sample of the population. Early life jumping traits can therefore optimize the genetic progress for show jumping performance." "The kinetics of glutathione in the gastrointestinal tract of weaned piglets supplemented with different doses of dietary reduced glutathione" "Yuhuang Hou, Joris Michiels, Céline Van Kerschaver, Mario Vandaele, Maryam Majdeddin, Els Vossen, Jeroen Degroote" "This study aimed to investigate the kinetics of dietary GSH in the gastrointestinal tract and the effect of GSH on the intestinal redox status of weaned piglets. Forty-eight piglets with an average age of 26 days and an average body weight of 7.7 kg were used in this study. The piglets were divided into three treatment groups including the control group with a basal diet (CON) and two GSH groups with a basal diet supplemented with 0.1% GSH (LGSH) and 1.0% GSH (HGSH), respectively. The basal diet did not contain any GSH. The experiment lasted for 14 days, with eight animals sampled from each group on d5 and 14. The parts of 0-5%, 5-75%, and 75-100% of the length of the small intestine were assigned to SI1, SI2, and SI3. The results showed that GSH almost completely disappeared from the digesta at SI2. However, no difference in the GSH level in mucosa, liver, and blood erythrocytes was found. The level of cysteine (CYS) in SI1 digesta was significantly higher in HGSH than CON and LGSH on d14, and similar findings were observed for cystine (CYSS) in SI3 digesta on d5. The CYSS level in HGSH was also significantly higher than LGSH in the stomach on d14, while no CYS or CYSS was detected in the stomach for control animals, indicating the breakdown of GSH to CYS already occurred in the stomach. Irrespective of the dietary treatment, the CYS level on d14 and the CYSS level on d5 and 14 were increased when moving more distally into the gastrointestinal tract. Furthermore, the mucosal CYS level was significantly increased at SI1 in the LGSH and HGSH group compared with CON on d5. Glutathione disulfide (GSSG) was recovered in the diets and digesta from the LGSH and HGSH group, which could demonstrate the auto-oxidation of GSH. It is, therefore, concluded that GSH supplementation could not increase the small intestinal mucosal GSH level of weaned piglets, and this could potentially relate to the kinetics of GSH in the digestive tract, where GSH seemed to be prone to the breakdown to CYS and CYSS and the auto-oxidation to GSSG." "Exploration and optimization of extraction, analysis and data normalization strategies for mass spectrometry-based DNA adductome mapping and modeling" "Stefaan De Smet, Lieselot Hemeryck" "Perspectives for DNA adductomics in large-scale exposomics : upscaling sample preparation and preprocessing data" "Lieselot Hemeryck, Stefaan De Smet" "Upscaling sample preparation, analysis and data preprocessing in DNA adductomics for large-scale exposomics" "Lieselot Hemeryck, Marilyn De Graeve, Thomas Van Hecke, Stefaan De Smet, Liesa Engelen, Roger Peró Gascón, Giulia Poma, Sarah De Saeger, Tim Nawrot, Adrian Covaci, Lynn Vanhaecke" "Differentially expressed genes in tissues of Pietrain sired pigs challenged with high figer/fat diet" "E. U. Nwosu, B. Chakkingal Bhaskaran, Eline Kowalski, W. Gorssen, R Meyermans, S. Janssens, Sam Millet, M. Aluwé, Stefaan De Smet, N. Buys" "Decrease of Salmonella and Escherichia coli O157:H7 counts during dry-aging of beef but potential growth of Listeria monocytogenes under certain dry-aging conditions" "Inge Van Damme, S Varalakshmi, Els Vossen, Stefaan De Smet" "In vitro stability and ex vivo absorption of thymol monoglucosides in the porcine gut" "Noémie Van Noten, Elout Van Liefferinge, Stefaan De Smet" "36-fold higher estimate of deaths attributable to red meat intake in GBD 2019 : is this reliable?" "Alice V. Stanton, Frédéric Leroy, Christopher Elliott, Neil Mann, Patrick Wall, Stefaan De Smet" "Quality of animal-source foods related to their production and processing conditions" "G. Richard, Stefaan De Smet, M. Font-i-Furnols, F. Leroy, V. Lind"