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In vitro regulation of Staphylococcus aureus growth and virulence by bovine non-aureus staphylococci : potential implications for udder health

Boek - Dissertatie

Staphylococcus aureus remains one of the most common causative agents of bovine mastitis because of its pathogenicity, contagiousness, capability to persist in the mammary gland, colonization of skin, and poor cure rates when causing intramammary infections with the currently available therapies. Therefore, alternative treatments and preventive measures are desirable to control S. aureus mastitis, especially when caused by methicillin-resistant strains (MRSA). In vitro and in vivo studies have suggested beneficial traits of non-aureus staphylococci (NAS) originating from bovine milk and teat apices (TA) against major pathogens such as S. aureus. More recent studies have speculated that interactions between S. aureus and other colonizing staphylococci via the quorum-sensing (QS) system might affect the ability of S. aureus to produce virulence factors such as biofilm, and cause infection, suggesting that NAS could be used as potential sources of metabolites to prevent or target S. aureus infections. The general aim of this thesis was to study some elements of the regulation of S. aureus growth and virulence, including biofilm formation, by bovine NAS, gauging for new venues for preventive or therapeutic measures against bovine S. aureus mastitis.
Jaar van publicatie:2021