< Terug naar vorige pagina

Publicatie

Type I interferons modulate CD8U+207A T cell immunity to mRNA vaccines

Tijdschriftbijdrage - Tijdschriftartikel

Ondertitel:Type I interferons modulate CD8(+) T cell immunity to mRNA vaccines
mRNA vaccines have emerged as potent tools to elicit antitumor T cell immunity. They are characterized by a strong induction of type I interferons (IFNs), potent inflammatory cytokines affecting T cell differentiation and survival. Recent reports have attributed opposing roles for type I IFNs in modulating CD8(+) T cell immunity to mRNA vaccines, from profoundly stimulatory to strongly inhibitory. The mechanisms behind this duality are unclear. Disentangling the factors governing the beneficial or detrimental impact of type I IFNs on CD8(+) T cell responses is vital to the design of mRNA vaccines of increased potency. In light of recent advancements regarding the complex role of type I IFNs in regulating CD8(+) T cell immunity to infectious diseases, we posit that the dual outcome of type I IFNs on CD8(+) T cell responses to mRNA vaccination is determined by the timing and intensity of type I IFN induction relative to T cell receptor (TCR) activation.
Tijdschrift: TRENDS IN MOLECULAR MEDICINE
ISSN: 1471-499X
Issue: 3
Volume: 23
Pagina's: 216 - 226
Jaar van publicatie:2017