< Terug naar vorige pagina


Thymocyte development in the absence of matrix metalloproteinase-9/gelatinase B

Tijdschriftbijdrage - Tijdschriftartikel

Matrix metalloproteinases (MMP) play critical roles in a variety of immune reactions by facilitating cell migration, and affect cell communication by processing both cytokines and cell surface receptors. Based on published data indicating that MMP-9 is upregulated upon T cell activation and also in the thymus upon the induction of negative selection, we investigated the contribution of MMP-9 into mouse T cell development and differentiation in the thymus. Our data suggest that MMP-9 deficiency does not result in major abnormalities in the development of any conventionally selected or agonist selected subsets and does not interfere with thymocyte apoptosis and clearance, and that MMP-9 expression is not induced in immature T cells at any stage of their thymic development.
Issue: 1
Volume: 6
Pagina's: 29852
Jaar van publicatie:2016
BOF-publication weight:2
CSS-citation score:1
Authors from:Higher Education