Synthesis of N-substituted 1,2,3,4-tetrahydrobenz[g]isoquinoline-5,10-diones

The synthesis of 1,2,3,4-tetrahydrobenz[g]isoquinoline-5,10-dione hydrochlorides is reported starting from 1,4-dihydrobenz[g]isoquinoline-3(2H)-ones or ethyl (3-aminomethyl-1,4-dimethoxynaphth-2-yl)- acetates. A third strategy relies on the synthesis of the title compounds via an N-protected 2-(3-bromomethyl- 1,4-dimethoxynaphth-2-yl)ethylamine. The synthesized 1,2,3,4-tetrahydro-benz[g]isoquinoline- 5,10-diones are a new class of quinones, which have not been reported yet.

Jaar van publicatie:2008

Trefwoorden:tetrahydroisoquinolines, naphthoquinones, naphthalene, benz[g]isoquinoline-3,5,10(2H)-triones