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Synthesis of N-Acyl Sulfamates from Fluorosulfates and Amides

Tijdschriftbijdrage - Tijdschriftartikel

A novel synthetic strategy toward  N-acyl sulfamates was developed. Interestingly, fluorosulfates, a new emerging class of electrophiles, were used to construct the sulfamate core. This precludes handling of chlorosulfonyl isocyanate and sulfamoyl chloride. In combination with amides, a wide and diverse set of N-acyl sulfamates was synthesized, including functionalized bioactive compounds. Furthermore, initial results showed that this method is also amenable to access N-thioacyl sulfamates.
Tijdschrift: Journal of Organic Chemistry
ISSN: 0022-3263
Issue: 2
Volume: 84
Pagina's: 1070 - 1078
Aantal pagina's: 9
Jaar van publicatie:2019