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Synthesis of densely functionalized pyrimidouracils by nickel(II)-catalyzed isocyanide insertion

Tijdschriftbijdrage - Tijdschriftartikel

A robust nickel-catalyzed oxidative isocyanide insertion/C-H amination by reaction of readily available N-uracil-amidines with isocyanides affording polysubstituted pyrimidouracils has been reported. The reaction proceeds in moderate to quantitative yield, under mild conditions (i.e., green solvent, air atmosphere, moderate temperature). The broad range of structurally diverse isocyanides and N-uracil-amidines that are tolerated make this method an interesting alternative to the currently available procedures toward pyrimidouracils.
Tijdschrift: Organic letters
ISSN: 1523-7060
Volume: 22
Pagina's: 914 - 919
Jaar van publicatie:2020
Trefwoorden:A1 Journal article