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Severe post-kala-azar dermal leishmaniasis successfully treated with miltefosine in an Ethiopian HIV patient

Tijdschriftbijdrage - Tijdschriftartikel

Post-kala-azar dermal leishmaniasis (PKDL) is a neglected tropical disease characterized by a dermatosis which often appears after successful treatment of visceral leishmaniasis caused by Leishmania donovani. PKDL treatment options are few and have severe limitations. In East-Africa, the standard treatment of PKDL is with daily painful potentially toxic sodium stibogluconate injections, administered for a prolonged duration of 30-60 days. In the Indian subcontinent, PKDL is mainly treated with miltefosine, a safer orally administered drug. However, in East-Africa, there is very limited experience in the use of miltefosine for treatment of severe PKDL, with only one published case report. Here we report a severe PKDL case in an Ethiopian HIV patient successfully treated with oral miltefosine (100mg/day for 28 days). Miltefosine was efficacious, safe and well tolerated, suggesting that it can play an important role in the treatment of severe PKDL also in East-African patients. Further research is warranted.

Tijdschrift: International Journal of Infectious Diseases
ISSN: 1201-9712
Volume: 81
Pagina's: 221-224
Jaar van publicatie:2019
Trefwoorden:Administration, Oral, Adult, Antiprotozoal Agents/administration & dosage, Ethiopia, HIV Infections/complications, Humans, Leishmania donovani/drug effects, Leishmaniasis, Cutaneous/drug therapy, Male, Phosphorylcholine/administration & dosage