Mood stabilizing drugs regulate transcription of immune, neuronal and metabolic pathway genes in Drosophila

Lithium and valproate (VPA) are drugs used in the management of bipolar disorder. Even though they reportedly act on various pathways, the transcriptional targets relevant for disease mechanism and therapeutic effect remain unclear. Furthermore, multiple studies used lymphoblasts of bipolar patients as a cellular proxy, but it remains unclear whether peripheral cells provide a good readout for the effects of these drugs in the brain.

Jaar van publicatie:2016

Trefwoorden:Psychiatrie en neurologie, Neurowetenschappen en Psychofarmacologie, Farmacologie en toxicologie

BOF-keylabel:ja

IOF-keylabel:ja

BOF-publication weight:1

CSS-citation score:1

Auteurs:International

Authors from:Government, Higher Education