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Publicatie

Mechanisms underlying connexin hemichannel activation in disease

Tijdschriftbijdrage - Tijdschriftartikel

Gap junctions and connexin hemichannels mediate intercellular and extracellular commu-nication, respectively. While gap junctions are seen as the “good guys” by controlling homeostasis, connexin hemichannels are considered as the “bad guys”, as their activation is associated with the onset and dissemination of disease. Open connexin hemichannels indeed mediate the transport of messengers between the cytosol and extracellular environment and, by doing so, fuel inflammation and cell death in a plethora of diseases. The present mini-review discusses the mechanisms involved in the activation of connexin hemichannels during pathology.

Tijdschrift: International Journal of Molecular Sciences
ISSN: 1661-6596
Issue: 7
Volume: 22
Pagina's: 1-13
Aantal pagina's: 13
Jaar van publicatie:2021
Trefwoorden:connexin hemichannel, pathology, mechanism, Multidisciplinaire scheikunde , Biochemie & -fysica en Moleculaire biologie