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L-Aspartic and L-glutamic acid ester-based ProTides of anticancer nucleosides: Synthesis and antitumoral evaluation

Tijdschriftbijdrage - Tijdschriftartikel

A series of novel aryloxyphosphoramidate nucleoside prodrugs based on l-aspartic acid and l-glutamic acid as amino acid motif has been synthesized and evaluated for antitumoral activity. Depending on the cancer cell line studied and on the nature of the parent nucleoside compound (gemcitabine, 5-iodo-2'-deoxy-uridine, floxuridine or brivudin), the corresponding ProTides are endowed with an improved or decreased cytotoxic activity.
Tijdschrift: Bioorganic & Medicinal Chemistry Letters
ISSN: 0960-894X
Issue: 9
Volume: 26
Pagina's: 2142 - 6
Jaar van publicatie:2016
BOF-keylabel:ja
IOF-keylabel:ja
BOF-publication weight:1
CSS-citation score:1
Authors from:Higher Education
Toegankelijkheid:Closed