< Terug naar vorige pagina


Insulitis in the pancreas of non-diabetic organ donors under age 25 years with multiple circulating autoantibodies against islet cell antigens

Tijdschriftbijdrage - Tijdschriftartikel

Autoantibodies against islet cell antigens are routinely used to identify subjects at increased risk of symptomatic type 1 diabetes, but their relation to the intra-islet pathogenetic process that leads to positivity for these markers is poorly understood. We screened 556 non-diabetic organ donors (3 months to 24 years) for five different autoantibodies and found positivity in 27 subjects, 25 single- and two double autoantibody-positive donors. Histopathological screening of pancreatic tissue samples showed lesion characteristic for recent-onset type 1 diabetes in the two organ donors with a high-risk profile, due to their positivity for multiple autoantibodies and HLA-inferred risk. Inflammatory infiltrates (insulitis) were found in a small fraction of islets (<5%) and consisted predominantly of CD3+CD8+ T-cells. Islets with insulitis were found in close proximity to islets devoid of insulin-positivity; such pseudo-atrophic islets were present in multiple small foci scattered throughout the pancreatic tissue or were found to be distributed with a lobular pattern. Relative beta cell area in both single and multiple autoantibody-positive donors was comparable to that in autoantibody-negative controls. In conclusion, in organ donors under age 25 years, insulitis and pseudo-atrophic islets were restricted to multiple autoantibody-positive individuals allegedly at high risk of developing symptomatic type 1 diabetes, in line with reports in older age groups. These observations may give further insight into the early pathogenetic events that may culminate in clinically overt disease.

Tijdschrift: Virchows Archiv : An International Journal of Pathology
ISSN: 0945-6317
Issue: 2
Volume: 479
Pagina's: 295-304
Jaar van publicatie:2021
Trefwoorden:BELCRO registry, Crohn's disease, health literacy, quality of life, type 1 diabetes mellitus
  • DOI: https://doi.org/10.1007/s00428-021-03055-z
  • Scopus Id: 85100924175
  • WoS Id: 000618585700001
  • ORCID: /0000-0002-9266-1660/work/99271618
  • ORCID: /0000-0001-5099-8962/work/99271731
  • ORCID: /0000-0003-3148-1372/work/99271793
  • ORCID: /0000-0001-5596-7129/work/99272166
  • ORCID: /0000-0002-9007-6177/work/99272511
  • ORCID: /0000-0002-8671-4527/work/99272639
  • ORCID: /0000-0001-8969-6531/work/99272729
  • ORCID: /0000-0002-9007-5203/work/99273095
  • ORCID: /0000-0003-4133-2565/work/99273112
BOF-publication weight:1
Authors from:Higher Education