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How to recognize inborn errors of immunity in a child presenting with a lymphoid malignancy: Guidelines for the pediatric haemato-oncologist.

Tijdschriftbijdrage - Tijdschriftartikel

Inborn errors of immunity (IEI) are a group of disorders caused by genetically determined defects in the immune system, leading to infections, autoimmunity, autoinflammation and an increased risk of malignancy. In some cases, a malignancy might be the first sign of an underlying IEI. As therapeutic strategies might be different in these patients, recognition of the underlying IEI by the pediatric hemato-oncologist is important. This article, written by a group of experts in pediatric immunology, hemato-oncology, pathology and genetics, aims to provide guidelines for pediatric hemato-oncologists on how to recognize a possible underlying IEI and what diagnostic tests can be performed, and gives some consideration to treatment possibilities.
Tijdschrift: Pediatric hematology and oncology
Issue: 2
Volume: 40
Pagina's: 131-146
Jaar van publicatie:2023