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The first potent diphenyl phosphonate KLK4 inhibitors with unexpected binding kinetics
Tijdschriftbijdrage - Tijdschriftartikel
KLK4 is a serine protease from the kallikrein family that is involved in cancer progression. The diphenyl phosphonate warhead is intended to bind irreversibly with serine proteases, but unexpectedly, very potent KLK4 diphenyl phosphonate inhibitors were discovered with reversible inhibition kinetics.
Tijdschrift: MedChemComm
ISSN: 2040-2503
Volume: 6
Pagina's: 1954 - 1958
Jaar van publicatie:2015
Trefwoorden:Chemistry, Biochemie & -fysica en Moleculaire biologie, Organische en medische scheikunde
BOF-keylabel:ja
BOF-publication weight:1
CSS-citation score:1
Auteurs:International
Authors from:Higher Education
Toegankelijkheid:Closed