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Facile construction of diverse polyheterocyclic scaffolds via gold-catalysed dearomative spirocyclization/1,6-addition cascade

Tijdschriftbijdrage - Tijdschriftartikel

A gold-catalysed post-Ugi chemo- and diastereoselective cascade dearomative spirocyclization/1,6-addition sequence is disclosed for the synthesis of diverse fused polyheterocyclic scaffolds bearing indole, pyrrole, benzothiophene, furan or electron-rich arene moieties from easily available building blocks. The effectiveness and efficiency of this diversity-oriented approach has been proved in the rapid construction of 28 fused polyheterocyclic scaffolds with a good building-block variability and structural complexity in two operational steps.
Tijdschrift: Organic & Biomolecular Chemistry
ISSN: 1477-0520
Issue: 25
Volume: 17
Pagina's: 6284 - 6292
Aantal pagina's: 9
Jaar van publicatie:2019
Trefwoorden:Organische en medische scheikunde