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DNA methylation profiling of non-small cell lung cancer reveals a COPD-driven immune-related signature

Tijdschriftbijdrage - Tijdschriftartikel

Non-small cell lung cancer (NSCLC) is a heterogeneous disorder consisting of distinct molecular subtypes each characterised by specific genetic and epigenetic profiles. Here, we aimed to identify novel NSCLC subtypes based on genome-wide methylation data, assess their relationship with smoking behaviour, age, COPD, emphysema and tumour histopathology, and identify the molecular pathways underlying each subtype.
Tijdschrift: THORAX
ISSN: 0040-6376
Issue: 12
Volume: 70
Pagina's: 1113 - 22
Jaar van publicatie:2015
BOF-keylabel:ja
IOF-keylabel:ja
BOF-publication weight:6
CSS-citation score:2
Authors from:Higher Education
Toegankelijkheid:Open