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Development of a Universal Anti-Adalimumab Antibody Standard for Interlaboratory Harmonization

Tijdschriftbijdrage - Tijdschriftartikel

Therapeutic drug monitoring of adalimumab (ADM) has been introduced recently. When no detectable ADM serum concentrations can be found, the formation of antidrug antibodies (ADA) should be investigated. A variety of assays to measure the occurrence of ADA have been developed. Results are expressed as arbitrary units or as a titration value. The aim was to develop a monoclonal antibody (MA) that could serve as a universal calibrator to quantify the amount of ADA in ADM-treated patients.
Tijdschrift: THERAPEUTIC DRUG MONITORING
ISSN: 0163-4356
Issue: 5
Volume: 36
Pagina's: 669 - 73
Jaar van publicatie:2014
BOF-keylabel:ja
IOF-keylabel:ja
BOF-publication weight:1
CSS-citation score:2
Authors from:Higher Education