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Construction and Evaluation of Quantitative Small-Animal PET Probabilistic Atlases for [(18)F]FDG and [(18)F]FECT Functional Mapping of the Mouse Brain

Tijdschriftbijdrage - Tijdschriftartikel

Automated voxel-based or pre-defined volume-of-interest (VOI) analysis of small-animal PET data in mice is necessary for optimal information usage as the number of available resolution elements is limited. We have mapped metabolic ([(18)F]FDG) and dopamine transporter ([(18)F]FECT) small-animal PET data onto a 3D Magnetic Resonance Microscopy (MRM) mouse brain template and aligned them in space to the Paxinos co-ordinate system. In this way, ligand-specific templates for sensitive analysis and accurate anatomical localization were created. Next, using a pre-defined VOI approach, test-retest and intersubject variability of various quantification methods were evaluated. Also, the feasibility of mouse brain statistical parametric mapping (SPM) was explored for [(18)F]FDG and [(18)F]FECT imaging of 6-hydroxydopamine-lesioned (6-OHDA) mice.
Tijdschrift: PLoS ONE
Issue: 6
Volume: 8
Aantal pagina's: 10
Jaar van publicatie:2013