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Composite yarns with antibacterial nanofibrous sheaths produced by collectorless alternating-current electrospinning for suture applications
Tijdschriftbijdrage - Tijdschriftartikel
Fabrication of strong antibacterial composite nanofibrous yarns (CNYs) for suture applications by using common direct current electrospinning has been technologically challenging. In this work, we have demonstrated a more straightforward and facile approach to fabricate chlorhexidine (CHX)-containing antibacterial nanofibrous sheaths wounded around a polyamide core yarn using a novel collectorless alternating-current electrospinning approach. Scanning electron microscopy results showed that the nanofibrous envelope was completely wrapped around the core yarn for both polymers, polyurethane, and polyamide 6 (PA6), used in this study. High-performance liquid chromatography after dissolving of the CNYs confirmed the presence of CHX in the yarns, while X-ray photoelectron spectroscopy and Fourier-transform infrared spectroscopy indicated that the amount is relatively low. The tensile properties of all the CNYs were better than of the core yarns and the CHX addition resulted in a lower envelope linear density and envelope adhesion force. Thermal gravimetric analysis showed that all CNYs are thermally stable within the temperature range of interest. Cytocompatibility tests with 3T3-SA mouse fibroblast cells and antibacterial evaluations with Escherichia coli and Staphylococcus aureus showed that the CHX-containing PA6-based CNYs are biocompatible and have antibacterial properties, suggesting that these yarns can be used as functional and mechanically performant sutures.
Tijdschrift: JOURNAL OF APPLIED POLYMER SCIENCE
Jaar van publicatie:2022