Chronic obstructive cholestasis with gallbladder masses associated with invasive fungal infection in a preterm neonate: a case report

A preterm boy, born at the gestational age of 26 weeks, developed a sepsis followed by obstructive cholestasis at the age of 4 weeks despite broad spectrum antibiotic and fluconazole treatment. Abdominal ultrasound showed masses of unknown origin in the gallbladder. An invasive fungal infection was diagnosed via serum (1,3)-beta-D-glucan. After initiation of the echinocandin caspofungin, inflammation and cholestasis parameters subsided quickly and the patient recovered. Accumulation of fungal balls in the gallbladder has been described as a cause of chronic obstructive cholestasis in immunocompromised adults, this is the first reported case in a preterm neonate.

Jaar van publicatie:2022

Trefwoorden:A1 Journal article

Toegankelijkheid:Open