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Choriocarcinoma in Situ in a Partial Hydatidiform Mole A Case Report

Tijdschriftbijdrage - Tijdschriftartikel

BACKGROUND: Choriocarcinoma most frequently arises in a complete hydatidiform mole. Less common are cases following a normal pregnancy or a nonmolar abortion. Its occurrence after a partial hydatidiform mole is extremely rare. CASE REPORT: Here we report a choriocarcinoma in situ diagnosed after dilation and curettage for a first tri- mester partial hydatidiform mole. The diagnosis was con- firmed by immunohistochemistry, fluorescent in situ hybridization, and microsatellite instability genotyping of the products of conception and blood of the mother and father. We demonstrated a diandric triploidy. At the time of diagnosis CT scan showed lung metastasis. The pa- tient was classified as high-risk gestational trophoblas- tic neoplasia and treated with high-dose methotrexate- etoposide. CONCLUSION: This is the first reported case of a cho- riocarcinoma arising in a first trimester partial mol.
Tijdschrift: Journal of Reproductive Medicine
ISSN: 0024-7758
Issue: 7-8
Volume: 61
Pagina's: 398 - 402
Aantal pagina's: 5
Jaar van publicatie:2016