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Cell surface clicking of antibody-recruiting polymers to metabolically azide-labeled cancer cells

Tijdschriftbijdrage - Tijdschriftartikel

Triggering antibody-mediated innate immune mechanisms to kill cancer cells is an attractive therapeutic avenue. In this context, recruitment of endogenous antibodies to the cancer cell surface could be a viable alternative to the use of monoclonal antibodies. We report on antibody-recruiting polymers containing multiple antibody-binding hapten motifs and cyclooctynes that can covalently conjugate to azides introduced onto the glycocalyx of cancer cells by metabolic labeling with azido sugars.
Tijdschrift: Chemical Communications
ISSN: 1359-7345
Issue: 73
Volume: 55
Pagina's: 10952 - 10955
Jaar van publicatie:2019
Trefwoorden:Multidisciplinaire scheikunde