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Case study: Angiotensin receptor blockers (ARBs)

Boekbijdrage - Hoofdstuk

here is now also ample evidence that the "residence time" of a drug at it cellular target (such as a receptor or an enzyme) may affect its clinical performance. In this respect, a great deal of attention has been devoted to those situations in where optimal clinical performance requires continuing, high levels of target occupancy. This has for example been proposed to be the case with AT1 receptor antagonist candesartan.
Boek: Kinetics and Thermodynamics of Drug binding
Series: Wiley's Methods and Principles in Medicinal Chemistry Series
Pagina's: 273-293
Aantal pagina's: 21
ISBN:978-3-527-33582-4
Jaar van publicatie:2015
Trefwoorden:angiotensin receptors, radioligand binding, sartans, rebinding, binding kinetics
  • Scopus Id: 84979719110