Autosomal-dominant Alzheimer's disease: a review and proposal for the prevention of Alzheimer's disease

ABSTRACT: Autosomal-dominant Alzheimer's disease has provided significant understanding of the pathophysiology of Alzheimer's disease. The present review summarizes clinical, pathological, imaging, biochemical, and molecular studies of autosomal-dominant Alzheimer's disease, highlighting the similarities and differences between the dominantly inherited form of Alzheimer's disease and the more common sporadic form of Alzheimer's disease. Current developments in autosomal-dominant Alzheimer's disease are presented, including the international Dominantly Inherited Alzheimer Network and this network's initiative for clinical trials. Clinical trials in autosomal-dominant Alzheimer's disease may test the amyloid hypothesis, determine the timing of treatment, and lead the way to Alzheimer's disease prevention.

Jaar van publicatie:2011

BOF-keylabel:ja

IOF-keylabel:ja

BOF-publication weight:6

CSS-citation score:4

Auteurs:International

Authors from:Government, Higher Education

Toegankelijkheid:Closed