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Analytical techniques for metabolomic studies

Tijdschriftbijdrage - Tijdschriftartikel

Ondertitel:a review

Metabolomics is the comprehensive study of small-molecule metabolites. Obtaining a wide coverage of the metabolome is challenging because of the broad range of physicochemical properties of the small molecules. To study the compounds of interest spectroscopic (NMR), spectrometric (MS) and separation techniques (LC, GC, supercritical fluid chromatography, CE) are used. The choice for a given technique is influenced by the sample matrix, the concentration and properties of the metabolites, and the amount of sample. This review discusses the most commonly used analytical techniques for metabolomic studies, including their advantages, drawbacks and some applications.

Tijdschrift: Bioanalysis
ISSN: 1757-6180
Issue: 24
Volume: 11
Pagina's: 2297-2318
Aantal pagina's: 22
Jaar van publicatie:2019
Trefwoorden:multiplatform approaches, separation techniques, spectrometric techniques, spectroscopic techniques, targeted metabolomics, untargeted metabolomics, Biochemie & -fysica en Moleculaire biologie, Analytische, anorganische en nucleaire scheikunde, Organische en medische scheikunde