< Terug naar vorige pagina


Aging effects on the resting state motor network and interlimb coordination

Tijdschriftbijdrage - Tijdschriftartikel

Both increases and decreases in resting state functional connectivity have been previously observed within the motor network during aging. Moreover, the relationship between altered functional connectivity and age-related declines in bimanual coordination remains unclear. Here, we explored the developmental dynamics of the resting brain within a task-specific motor network in a sample of 128 healthy participants, aged 18-80 years. We found that age-related increases in functional connectivity between interhemispheric dorsal and ventral premotor areas were associated with poorer performance on a novel bimanual visuomotor task. Additionally, a control analysis performed on the default mode network confirmed that our age-related increases in functional connectivity were specific to the motor system. Our findings suggest that increases in functional connectivity within the resting state motor network with aging reflect a loss of functional specialization that may not only occur in the active brain but also in the resting brain. Hum Brain Mapp, 2014. © 2014 Wiley Periodicals, Inc.
Tijdschrift: Human Brain Mapping
ISSN: 1065-9471
Issue: 8
Volume: 35
Pagina's: 3945 - 61
Jaar van publicatie:2014
BOF-publication weight:3
CSS-citation score:2
Authors from:Higher Education