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The 1,3-diyne linker as a rigid 'i,i+7' staple for α-helix stabilization : stereochemistry at work

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Ondertitel:The 1,3-diyne linker as a rigid 'i,i+7' staple for alpha-helix stabilization : stereochemistry at work
Short alphahelical peptide sequences were stabilized through Glaser-Hay couplings of propargylated l- and/or d-serine residues at positions i and i+7. NMR analysis confirmed a full stabilization of the helical structure when a d-Ser (i), l-Ser (i+7) combination was applied. In case two l-Ser residues were involved in the cyclization, the helical conformation is disrupted outside the peptide's macrocycle.
Tijdschrift: JOURNAL OF PEPTIDE SCIENCE
ISSN: 1075-2617
Issue: 7
Volume: 25
Jaar van publicatie:2019
BOF-keylabel:ja
IOF-keylabel:ja
BOF-publication weight:0.1
Auteurs:National
Authors from:Private
Toegankelijkheid:Closed