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In silico medicine for thoracic aortic aneurysm treatment through integrative multiscale mechanobiological modeling

A thoracic aortic aneurysm is a life threatening condition. Current research aimed at improving treatment approaches is fragmented and divided over multiple research fields. This project is aimed at bridging the gap between biomechanical models that often lack biological validation and insights from vascular biology that study very detailed signaling processes with a limited global view. In order to enable in silico medicine, we will develop a computational tool for the prediction of aneurysm growth, based on a systems biology inspired cell level regulatory model, combined with a tissue-level model of extracellular matrix adaptation over time. Combined with patient-specific finite element models of the thoracic aorta, this will allow personalized treatment and risk prevention.
Datum:1 okt 2022 →  Heden
Trefwoorden:Thoracic aortic aneurysm, In silico medicine, Gene regulatory network, Mechanobiological homeostasis, Multiscale mechanical modeling
Disciplines:Moleculaire en cellulaire biomechanica, Weefsel- en orgaanbiomechanica, Biomedische modellering, Bio-informatica data-integratie en netwerkbiologie