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To define innate immune responses in patients infected with schistosomes that are associated with down-regulation of acquired immune responses, or conversely the development of pathology.To characterise and manufacture parasite-derived immunoregulatory molecules.To use parasite-derived molecules to manipulate protective immune responses and immunopathology.To aid existing control programmes by using epidemiological and geographic data gathered in the field.
Project
Novel mechanism in the control of infection and disease (SCHISTOINIR)
General
The long-term objective is to improve effectiveness of control programmes (i.e drug treatment and putative anti-schistosome vaccines), or alternatively, to promote immunoregulatory networks in individuals with severe morbidity.
Specific
To define innate immune responses in patients infected with schistosomes that are associated with down-regulation of acquired immune responses, or conversely the development of pathology.To characterise and manufacture parasite-derived immunoregulatory molecules.To use parasite-derived molecules to manipulate protective immune responses and immunopathology.To aid existing control programmes by using epidemiological and geographic data gathered in the field.
Datum:1 nov 2006 → 31 okt 2010
Project type:PhD project