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Project

Nieuwe algorithmes voor de analyse van DNA microarray gegevens.

DNA microarrays have known a widespread development in the past years. Currently a lot of research of molecular biology is based on the use of microarrays. Compared to the first prototypes of the mid-nineties, the technology has advanced considerably in terms of reliability and cross-platform agreement. One of the present weaknesses of microarrays, where probably most work has to be done, is in the data analysis. Several algorithms, either publicity available or developed by commercial companies, are currently being used. These algorithms rely on statistical analysis and are based on some ad-hoc assumptions about normalization and data summarization. It is the aim of this project to develop a novel class of algorithms which are based on the physics of the hybridization process, which will be described by the help of models from equilibrium and non-equilibrium thermodynamics. The project is interdisciplinary ans will involve close collaborations between physicists of the Institute for theoretical Physics and bioinformaticians of ESAT. It also envisages exchanges with some experimental groups of the Faculty of Medicine and in particular of the Clinical Genetics Section of the KULeuven. The focus of this study are mainly Affymetrix arrays for expression and CGH analysis. The algorithms developed will be turned into freely available software for the scientific community.
Datum:1 okt 2009 →  30 sep 2015
Trefwoorden:Novel algorithms, DNA microarrays