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Project

Hoe interageren stamcellen mechanische met hun extracellulaire matrix en wat zijn de mechanobiologische gevolgen voor skeletale weefselengineering? Een computationeel-modelmatige benadering, gevoed door in vitro experimenten.

The use of hydrogels enriched with stem cells appears to be a very promising strategy in regenerative medicine. A crucial issue in this approach is how to control stem cell behaviour to achieve a functional tissue. The mechanical signals that cells receive from their microenvironment have been found to be an important regulator of their behaviour. Thereby, it is possible to regulate the behaviour of stem cells utilising a combination of strategies informed by mechanical clues. However, this approach requires quantitative evaluation of the mechanical signals that cells receive from their matrix and relating these signals to their behaviour, i.e. proliferation, differentiation and migration. This study aims to address the role of mechanical signals in regulating tissue patterning (i.e. cartilage and bone formation) in periosteum derived stem cell enriched hydrogels using computational models informed by in-vitro cell culture experiments.
Datum:1 okt 2011 →  30 sep 2014
Trefwoorden:Computational modelling, Hydrogel, Periosteum derived stem cell, Skeletal tissue engineering, Mechanobiology