< Terug naar vorige pagina
Project
Antimalarial treatment efficacy and safety in pregnant women
Main Objective is to assess the safety and efficacy of three artemesinin-based combination therapies (ACTs) (mefloquine-artesunate, dihydroartemisinin-piperaquine and artemetherlumefantrine) for the treatment of malaria in Zambian pregnant women. This study will be done in Nchelenge district of Luapula province, Zambia.
Specific Objectives:
1. To characterise the malaria endemicity in Nchelenge district;
2. To determine the safety and efficacy of mefloquine-artesunate, dihydroartemisininpiperaquine and artemether-lumefantrine in treating pregnant women with a P. falciparum malaria infection;
3. To compare the impact of the three treatments on the pregnancy outcome e.g. placental malaria, birth weight, congenital malformations on the infant;
4. To determine the relationship between drug levels (partner drug) at day 7 and response to treatment;
5. To determine the impact of malaria preventive measures as IPT, ITN and ACT treatment on the pregnancy outcome e.g. placental malaria, birth weight, congenital malformations on the infant.
Specific Objectives:
1. To characterise the malaria endemicity in Nchelenge district;
2. To determine the safety and efficacy of mefloquine-artesunate, dihydroartemisininpiperaquine and artemether-lumefantrine in treating pregnant women with a P. falciparum malaria infection;
3. To compare the impact of the three treatments on the pregnancy outcome e.g. placental malaria, birth weight, congenital malformations on the infant;
4. To determine the relationship between drug levels (partner drug) at day 7 and response to treatment;
5. To determine the impact of malaria preventive measures as IPT, ITN and ACT treatment on the pregnancy outcome e.g. placental malaria, birth weight, congenital malformations on the infant.
Datum:1 nov 2009 → 20 dec 2019
Trefwoorden:B780-tropische-geneeskunde