MCL-1 AS CRITICAL REGULATOR OF FOXP3+ REGULATORY T CELL SURVIVAL, AND USE THEREOF TO TREAT SEVERE IMMUNE DISORDERS

The present application relates to the field of immunology, more particularly to diseases and disorders characterized by insufficient numbers of Foxp3 positive regulatory T cells (Tregs). The mechanisms of the homeostatic processes that regulate the Treg numbers were studied, and it was found that Mcl-expression is critical for Treg survival. As most studies aiming at increasing Treg numbers to modulate immunity only achieve a transient increase, this finding has important therapeutic consequences: combined Mcl-1 and Foxp3 expression results in a stable population of Treg cells; enhancing Treg numbers will result in clinical improvement in many severe immune disorders.

Octrooi-publicatienummer: WO2014180943

Jaar aanvraag: 2014

Jaar toekenning: 2015

Jaar van publicatie: 2014

Status: Aangevraagd

Technologiedomeinen: Farmaceutische producten

Gevalideerd voor IOF-sleutel: Ja

Toegewezen aan: Associatie KULeuven