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Organisatie
Therapeutische en Diagnostische Antilichamen
Division
Hoofdorganisatie:Departement Farmaceutische en Farmacologische Wetenschappen
Tijdsduur:1 apr 2013 → Heden
Organisatieprofiel:
Since over 25 years the laboratory focusses on the generation and characterization of monoclonal antibodies (Mabs), antibody derivatives, nanobodies and diabodies and application as either therapeutics, diagnostics or research tools.
Major research lines include:
- Studies on structure-function relationship in proteins involved in cardiovascular disease (e.g. Plasminogen Activator inhibitor-1 (PAI-1) and Thrombin Activatable Fibrinolysis Inhibitor (TAFI))
- Therapeutic drug monitoring and evaluation of immunogenicity with a particular focus on therapeutic monoclonal antibodies used in chronic inflammatory diseases (e.g. Inflammatory Bowel Disease (IBD) and Rheumatoid Arthritis (RA))
- Development of a DNA-based platform for the in vivo expression of therapeutic monoclonal antibodies (mAbs).
Trefwoorden:Monclonal Antibodies, Therapeutic Drug Monitoring, Gene Therapy
Disciplines:Laboratoriumgeneeskunde, Regeneratieve geneeskunde, Andere basiswetenschappen, Andere gezondheidswetenschappen, Andere medische en gezondheidswetenschappen, Medische biotechnologie, Farmaceutica, Ontdekking en evaluatie van geneesmiddelen