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Organisatie
Steyaert Lab
Research Group
Hoofdorganisatie:VIB-VUB Center for Structural Biology
Tijdsduur:1 jan 2017 → Heden
Organisatieprofiel:Exploiting nanobodies for drug discovery on difficult targets like GPCRs and on the engineering of nanobodies to be used in single particle cryo-EM and OMICs applications.
Trefwoorden:Molecular Biophysics, protein networks, Macromolecules, crystallography
Disciplines:Medicinale en biomoleculaire chemie, Biochemie en metabolisme, Biofysica
Huidige onderzoekers
1 - 10 of 22 results
- Jan Steyaert (Verantwoordelijke)
- Marjolijn Berghmans (Lid)
- Thomas Dal Maso (Lid)
- Phebe De Keyser (Lid)
- Babette Deckers (Lid)
- Baptiste Fischer (Lid)
- Galicia Christian (Lid)
- Danae Giakoumakis (Lid)
- Steven Janvier (Lid)
- Valentina Kalichuk (Lid)
Projecten
1 - 9 of 9
- Integrated Services for Infectious Disease Outbreak Research (ISIDORe)Vanaf1 feb 2022 → HedenFinanciering: Andere Eu-programma's en intiatieven
- VIB Grant for Steyaert Lab_Period:2022-01-01-2026-12-31Vanaf1 jan 2022 → HedenFinanciering: VOI - Projectmatig onderzoek
- GBA stabilization and activation through nanobodies and derived peptide mimetics in neuronal modelsVanaf1 sep 2021 → HedenFinanciering: Buitenl. stichtingen, fondsen e.d. met wet. oogmerk
- GBA1 stabilization through nanobodies : a versatile tool to improve wild type and mutant enzyme functionVanaf1 aug 2019 → 31 jan 2021Financiering: Buitenl. stichtingen, fondsen e.d. met wet. oogmerk
- Biochemical and structural characterization of LRRK2-specific nanobodiesVanaf27 jul 2019 → 26 jul 2021Financiering: Buitenl. stichtingen, fondsen e.d. met wet. oogmerk
- Application of novel nanobodies to existing LRRK2 biomarker assays for the segregation of affected patients in multiple cohorts of familial and idiopathic PDVanaf1 dec 2018 → 30 nov 2020Financiering: Buitenl. stichtingen, fondsen e.d. met wet. oogmerk
- Conformation-specific nanobodies for biochemical, functional and structural characterization of LRRK2Vanaf15 jun 2017 → 14 jun 2019Financiering: Buitenl. stichtingen, fondsen e.d. met wet. oogmerk
- VIB Grant for Steyaert Lab_Period:2017-01-01-2021-12-31Vanaf1 jan 2017 → 31 dec 2021Financiering: VOI - Projectmatig onderzoek
- Releasing the full potential of Instruct to expand and consolidate infrastructure services for integrated structural life science researchVanaf1 jan 2017 → 31 dec 2020Financiering: Andere Eu-programma's en intiatieven
Publicaties
1 - 10 van 113
- Fructose-1,6-bisphosphate couples glycolytic flux to activation of Ras(2017)
Auteurs: Frederik Van Leemputte, Baptiste Fischer, Ward Vanthienen, Peter Tompa, Wim Versées, Johan Thevelein
Pagina's: 922 - Structural basis for the allosteric modulation of rhodopsin by nanobody binding to its extracellular domain.(2023)
Auteurs: Els Pardon, Jan Steyaert
Pagina's: 5209 - Structure of S-layer protein Sap reveals a mechanism for therapeutic intervention in anthrax.(2019)
Auteurs: Antonella Fioravanti, Filip Van Hauwermeiren, Sander Van der Verren, Amanda Gonçalves, Els Pardon, Jan Steyaert, Henri De Greve, Mohamed Lamkanfi, Han Remaut
Pagina's: 1805-1814 - Conformational transitions and ligand-binding to a muscle-type nicotinic acetylcholine receptor.(2022)
Auteurs: Tomasz Uchanski, Jan Steyaert
Pagina's: 1358-1370.e5 - Structure and function of the EA1 surface layer of Bacillus anthracis.(2023)
Auteurs: Adria Sogues Castrejon, Antonella Fioravanti, Els Pardon, Jan Steyaert, Han Remaut
Pagina's: 7051 - Structures of ligand-occupied beta-Klotho complexes reveal a molecular mechanism underlying endocrine FGF specificity and activity(2019)
Auteurs: Els Pardon, Jan Steyaert
Pagina's: 7819-7824 - Plasticity of the binding pocket in peptide transporters underpins promiscuous substrate recognition.(2023)
Auteurs: Els Pardon, Jan Steyaert
Pagina's: 112831 - Diversity in kinetics correlated with structure in nano body-stabilized LacY.(2020)
Auteurs: Els Pardon, Jan Steyaert
Pagina's: e0232846 - Modulation of the Erwinia ligand-gated ion channel (ELIC) and the 5-HT3 receptor via a common vestibule site.(2020)
Auteurs: Els Pardon, Jan Steyaert
Pagina's: E51511 - Mobile barrier mechanisms for Na+-coupled symport in an MFS sugar transporter.(2024)
Auteurs: Els Pardon, Jan Steyaert
Pagina's: RP92462