Onderzoeker
Wenting Guo
- Disciplines:Systeembiologie, Biochemie en metabolisme, Medische biochemie en metabolisme
Affiliaties
- Biochemie, Moleculaire en Structurele Biologie (Afdeling)
Lid
Vanaf1 jun 2022 → 31 dec 2022 - Stamcel- en Ontwikkelingsbiologie (Afdeling)
Lid
Vanaf1 okt 2017 → 31 mei 2022 - Laboratorium voor Neurobiologie (VIB-KU Leuven) (Labo)
Lid
Vanaf1 okt 2013 → 30 sep 2017
Projecten
1 - 1 of 1
- Pooled CRISPR/Cas9 screen in humane stamcel-gedifferentieerde motorneuronen om nieuwe therapeutische doelwitten voor amyotrofe laterale sclerose te identificerenVanaf1 okt 2018 → 30 sep 2019Financiering: BOF - postdoctorale mandaten
Publicaties
11 - 20 van 22
- Mutant FUS causes DNA ligation defects to inhibit oxidative damage repair in Amyotrophic Lateral Sclerosis(2018)
Auteurs: Wenting Guo, Tijs Vandoorne, Ludo Van Den Bosch
- Efficient Recombinase-Mediated Cassette Exchange in hPSCs to Study the Hepatocyte Lineage Reveals AAVS1 Locus-Mediated Transgene Inhibition(2018)
Auteurs: Laura Ordovas Vidal, Ruben Boon, Elena Pistoni, Yemiao Chen, Esther Wolfs, Wenting Guo, Rangarajan Sambathkumar, Sylwia Bobis-Wozowicz, Nicky Helsen, Jolien Vanhove, et al.
Pagina's: 673 - Therapeutic potential of HDAC6 in amyotrophic lateral sclerosis(2018)
Auteurs: Wenting Guo, Ludo Van Den Bosch
Pagina's: 14 - 16 - HDAC6 inhibition reverses axonal transport defects in motor neurons derived from FUS-ALS patients(2017)
Auteurs: Wenting Guo, Laura Fumagalli, Tijs Vandoorne, Ruben Boon, Samie PATEL, Tine Tricot, Veronick Benoy, Jolien Steyaert, Werend Boesmans, Pieter Vanden Berghe, et al.
Pagina's: 861 - Current advances and limitations in modeling ALS/FTD in a dish using induced pluripotent stem cells(2017)
Auteurs: Wenting Guo, Laura Fumagalli, Robert Ciarán Prior, Ludo Van Den Bosch
- Motor neurons derived from ALS patients with FUS mutations mimic disease-related phenotypes in vitro(2016)
Auteurs: Wenting Guo, Laura Fumagalli, Samie PATEL, Pieter Vanden Berghe, Wim Robberecht, Patrick Dupont, Philip Van Damme, Catherine Verfaillie, Ludo Van Den Bosch
- Generation and motor neuron differentiation of integration-free induced pluripotent stem cells (iPSCs) from ALS patients harboring FUS mutations(2015)
Auteurs: Wenting Guo, Samie PATEL, Philip Van Damme, Catherine Verfaillie, Ludo Van Den Bosch
- Efficient recombinase-mediated cassette exchange in hPSCs to study the hepatocyte lineage reveals AAVS1 locus-mediated transgene inhibition(2015)
Auteurs: L Ordovás, Ruben Boon, M Pistoni, Y Chen, Esther Wolfs, Wenting Guo, R Sambathkumar, S Bobis-Wozowicz, N Helsen, J Vanhove, et al.
Pagina's: 918 - 931 - Erratum: Efficient Recombinase-Mediated Cassette Exchange in hPSCs to Study the Hepatocyte Lineage Reveals AAVS1 Locus-Mediated Transgene Inhibition (Stem Cell Reports (2015) 5(5) (918–931)(S2213671115002660)(10.1016/j.stemcr.2015.09.004))(2015)
Auteurs: L Ordovás, Ruben Boon, M Pistoni, Y Chen, Esther Wolfs, Wenting Guo, R Sambathkumar, S Bobis-Wozowicz, N Helsen, J Vanhove, et al.
Pagina's: 673 - Efficient recombinase mediated cassette exchange in hPSC to study the hepatocyte lineage reveals AAVS1 locus-mediated transgene inhibition(2015)
Auteurs: Laura Ordovas Vidal, Ruben Boon, Elena Pistoni, Yemiao Chen, Esther Wolfs, Wenting Guo, Rangarajan Sambathkumar, Nicky Helsen, Jolien Vanhove, Kim Vanuytsel, et al.
Pagina's: 918 - 931
Patenten
1 - 1 van 1
- Nek6 inhibition to treat als and ftd (Inventor)