Onderzoeker
Stephen Weeks
- Disciplines:Analytische chemie, Medicinale en biomoleculaire chemie, Biochemie en metabolisme, Moleculaire en celbiologie, Plantenbiologie, Systeembiologie, Biofysica, Medische biochemie en metabolisme, Ontdekking en evaluatie van biomarkers, Ontdekking en evaluatie van geneesmiddelen, Medicinale producten, Farmaceutica, Farmacognosie en fytochemie, Farmacologie, Farmacotherapie, Toxicologie en toxinologie, Andere farmaceutische wetenschappen
Affiliaties
- Biokristallografie (Afdeling)
Lid
Vanaf6 apr 2009 → 31 mrt 2019
Projecten
1 - 5 of 5
- Structurele en functionele studies van antibiotica producerende eiwittenVanaf1 okt 2016 → 23 sep 2020Financiering: Eigen Middelen zoals patrimonium, inschrijvingsgelden, giften, ....
- Modernisering en capaciteitsuitbreiding voor de Macromoleculaire Kristallografische FaciliteitVanaf1 okt 2016 → 30 sep 2018Financiering: Fonds Recuperatie Fiscale Vrijstelling
- Karakterisatie van de moleculaire interactie tussen intermediaire filamenten en kleine 'heat shock' eiwittenVanaf1 jan 2016 → 31 dec 2018Financiering: FWO Krediet aan Navorser
- Rationeel ontwerp van nieuwe antibiotica op basis van tRNA synthetase inhibitoren.Vanaf1 okt 2014 → 30 sep 2018Financiering: BOF - Geconcert. Onderzoeksacties vanaf 1994
- Structurele studies van complexen van kleine heatshock eiwitten.Vanaf1 sep 2010 → 31 aug 2014Financiering: Marie Curie - Mensen
Publicaties
1 - 10 van 30
- Structural Characterization of Aminoacyl-tRNA Synthetase Inhibitors as Antibiotics and Tools for Enzyme Mechanistic Studies(2020)
Auteurs: Luping Pang, Arthur Van Aerschot, Sergei Strelkov, Stephen Weeks
- Structural studies of aminoacyl-tRNA synthetases: development of new antibiotics(2020)
Auteurs: Steff De Graef, Sergei Strelkov, Arthur Van Aerschot, Stephen Weeks
- Design and synthesis of various nucleoside analogues as aminoacyl-tRNA synthetase inhibitors(2019)
Auteurs: Manesh Nautiyal, Arthur Van Aerschot, Stephen Weeks, Bharat Gadakh
- Rational design of an XNA ligase through docking of unbound nucleic acids to toroidal proteins(2019)
Auteurs: Michiel Vanmeert, Muhammad Usman Mirza, Stephen Weeks, Jef Rozenski, Mathy Froeyen, Piet Herdewyn, Vitor Bernardes Pinheiro, Eveline Lescrinier
Pagina's: 1 - 12 - Acylated sulfonamide adenosines as potent inhibitors of the adenylate-forming enzyme superfamily(2019)
Auteurs: Dries De Ruysscher, Luping Pang, Steff De Graef, Manesh Nautiyal, Wim De Borggraeve, Jef Rozenski, Sergei Strelkov, Stephen Weeks, Arthur Van Aerschot
Pagina's: 252 - 264 - Comparative analysis of pyrimidine substituted aminoacyl-sulfamoyl nucleosides as potential inhibitors targeting class I aminoacyl-tRNA synthetases(2019)
Auteurs: Manesh Nautiyal, Steff De Graef, Luping Pang, Sergei Strelkov, Stephen Weeks, Arthur Van Aerschot
Pagina's: 154 - 166 - Discovery of a new Pro-Pro endopeptidase, PPEP-2, provides mechanistic insights into the differences in substrate specificity within the PPEP family(2018)
Auteurs: Oleg Klychnikov, Stephen Weeks, Sergei Strelkov
Pagina's: 11154 - 11165 - The Role of the Arginine in the Conserved N-Terminal Domain RLFDQxFG Motif of Human Small Heat Shock Proteins HspB1, HspB4, HspB5, HspB6, and HspB8(2018)
Auteurs: Stephen Weeks, Sergei Strelkov
- Family wide analysis of aminoacyl-sulfamoyl-3-deaza-adenosine analogues as inhibitors of aminoacyl-tRNA synthetases(2018)
Auteurs: Baole Zhang, Steff De Graef, Manesh Nautiyal, Luping Pang, Bharat Gadakh, Mathy Froeyen, Lieve Vanmellaert, Sergei Strelkov, Stephen Weeks, Arthur Van Aerschot
Pagina's: 384 - 396 - Characterization of human small heat shock protein HSPB1 alpha-crystallin domain localized mutants associated with hereditary motor neuron diseases(2018)
Auteurs: Stephen Weeks, Michelle Heirbaut, Sergei Strelkov