Onderzoeker
Joost Schymkowitz
- Trefwoorden:Toegepaste biologische wetenschappen
- Disciplines:(Bio)medische ingenieurswetenschappen
Affiliaties
- Toegepaste Biologische Wetenschappen (Departement)
Lid
Vanaf1 apr 2004 → 31 mrt 2010 - Eiwit conformatie en cellulaire controle (Onderzoeksgroep)
Lid
Vanaf1 sep 2003 → 31 mrt 2010
Projecten
1 - 2 of 2
- Structurele en biofysische karakterisatie van toxische oligomeren van het Alzheimer's beta-peptide.Vanaf1 jan 2009 → 31 dec 2012Financiering: FWO Onderzoeksproject (incl. WEAVE projecten)
- Een multidisciplinaire analyse van aan de Ziekte van Alzheimer geassocieerde risicofactoren en de toxiciteit van Aß aggregatieVanaf1 jan 2009 → 31 dec 2013Financiering: FWO Odysseus
Publicaties
1 - 10 van 40
- EndophilinA-dependent coupling between activity-induced calcium influx and synaptic autophagy is disrupted by a Parkinson-risk mutation(2023)
Auteurs: Adekunle T Bademosi, Marianna Decet, Sabine Kuenen, Carles Calatayud, Jef Swerts, Sandra F Gallego, Nils Schoovaerts, Spyridoula Karamanou, Nikolaos Louros, Ella Martin, et al.
Pagina's: 1402-1422.e13 - Liquid-Liquid Phase Separation Enhances TDP-43 LCD Aggregation but Delays Seeded Aggregation(2021)
Auteurs: Donya Pakravan, Emiel Michiels, Anna Bratek-Skicki, Mathias De Decker, Joris Van Lindt, David Alsteens, Sylvie Derclaye, Philip Van Damme, Joost Schymkowitz, Frederic Rousseau, et al.
- Structural Basis of the Subcellular Topology Landscape of Escherichia coli(2019)
Auteurs: Maria S Loos, Reshmi Ramakrishnan, Wim Vranken, Alexandra Tsirigotaki, Evrydiki-Pandora Tsare, Valentina Zorzini, Jozefien De Geyter, Biao Yuan, Ioannis Tsamardinos, Maria Klappa, et al.
Pagina's: 1-22 - Loss of DPP6 in neurodegenerative dementia(2019)
Auteurs: Rita Cacace, Bavo Heeman, Sara Van Mossevelde, Arne De Roeck, Julie Hoogmartens, Peter De Rijk, Helena Gossye, Kristof De Vos, Wouter De Coster, Mojca Strazisar, et al.
Pagina's: 901-918 - Frizzled 7 and PIP2 binding by syntenin PDZ2 domain controls Frizzled 7 trafficking and signaling.(2016)
Auteurs: Antonio Egea-Jimenez, Rodrigo Gallardo, Abel Garcia-Pino, Ylva Ivarsson, Anna Maria Wawrzyniak, Rudra Kashyap, Remy Loris, Joost Schymkowitz, Frederic Rousseau, Pascale Zimmermann
- From Binding-Induced Dynamic Effects in SH3 Structures to Evolutionary Conserved Sectors(2016)
Auteurs: Ana Zafra Ruano, Elisa Cilia, José R Couceiro, Javier Ruiz Sanz, Joost Schymkowitz, Frederic Rousseau, Irene Luque, Tom Lenaerts
- Molecular plasticity regulates oligomerization and cytotoxicity of the multipeptide-length amyloid-β peptide pool(2012)
Auteurs: Annelies Vandersteen, Marcelo F Masman, Greet De Baets, Wim Jonckheere, Kees Van Der Werf, Siewert J. Marrink, Jef Rozenski, Iryna Benilova, Bart Destrooper, Vinod Subramaniam, et al.
Pagina's: 36732-36743 - α-Galactosidase Aggregation Is a Determinant of Pharmacological Chaperone Efficacy on Fabry Disease Mutants(2012)
Auteurs: Aleksandra Siekierska, Greet De Baets, Joke Reumers, Rodrigo Gallardo Tapia, Stanislav Rudyak, Kerensa Broersen, Couceiro Jose, Joost Van Durme, Joost Schymkowitz, Frederic Rousseau
Pagina's: 28386-28397 - Aggregation gatekeepers modulate protein homeostasis of aggregating sequences and affect bacterial fitness(2012)
Auteurs: Jacinte Beerten, Wim Jonckheere, Stanislav Rudyak, Jie Xu, Hannah Wilkinson, Frederik De Smet, Joost Schymkowitz, Frederic Rousseau
Pagina's: 357-366 - Structural Basis for Increased Toxicity of Pathological Aβ42:Aβ40 Ratios in Alzheimer Disease(2012)
Auteurs: K. Pauwels, Tl Williams, Kl Morris, Wim Jonckheere, Annelies Vandersteen, G. Kelly, Joost Schymkowitz, Frederic Rousseau, Annalisa Pastore, Louise Serpell, et al.
Pagina's: 5650-5660
Patenten
1 - 8 van 8
- Methods for screening inhibitors of tumour associated protein aggregation. (Inventor)
- Molecules and methods for inhibition and detection of proteins (Inventor)
- Means and methods for mediating protein interference
- Methods for screening inhibitors of tumor associated protein aggregation
- Targeted induction of aggregation of proteins with cross beta structures (Inventor)
- Extracellular allosteric inhibitor binding domain from a tyrosine kinase receptor (Inventor)
- Extracellular allosteric inhibitor binding domain from a tyrosine kinase receptor
- Molecules and methods for inhibition and detection of proteins